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89510

Sigma-Aldrich

Poly(éthylène glycol)

BioUltra, 8,000

Synonyme(s) :

PEG

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250 G
37,00 €
1 KG
122,00 €

About This Item

Formule linéaire :
H(OCH2CH2)nOH
Numéro CAS:
25322-68-3
Numéro MDL:
MFCD00081839
Code UNSPSC :
12352104
ID de substance PubChem :
24889230
Nomenclature NACRES :
NA.26

37,00 €

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Gamme de produits

BioUltra

Forme

solid

Poids mol.

Mr 7000-9000

Impuretés

insoluble matter:, passes filter test
≤0.001% peroxides (as H2O2):

pH

5.5-7.0 (25 °C, 50 mg/mL in H2O)

Pf

61-64 °C

Solubilité

H2O: 50 mg/mL at 25 °C, clear, colorless

Traces d'anions

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

Traces de cations

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

50 mg/mL in H2O

Absorption UV

λ: 260 nm Amax: 0.09
λ: 280 nm Amax: 0.03

Chaîne SMILES 

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

Clé InChI

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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Description générale

Poly(ethylene glycol) (PEG) is a polymer of ethylene glycol units and is hydrophilic in nature. PEG has high hydration capacity and is structurally flexible. PEG has advantage as a drug conjugate due to biocompatibility and nonexistence of steric hindrances in its structure.[1]

Application

Poly(ethylene glycol) has been used:
  • in the transformation buffer in yeast[2]
  • as a constituent of dengue virus isolation buffer[3]
  • for concentration of lentivirus particles[4]
  • in the crystallization of herpesvirus nuclear egress complex (NEC)[5]

Actions biochimiques/physiologiques

The Food and Drug Administration (FDA) approved PEG as drug conjugates, is nonimmunogenic and safe.[6] PEG is widely used as a reagent in biochemistry and molecular biology experiments.[7] PEG conjugation improves solubility and dissolution of diabetes drug, Gliclazide.[8] It is used in carbon nanotube functionalization.[9] The presence of PEG 8000 in the tannin tree foliage improves metabolisable energy (ME) content and gas production.[10]

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
BCCN0122
BCCL9738
BCCM5349
BCCL0773
BCCH8679

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Poly(éthylène glycol) average Mn 6,000

Sigma-Aldrich

81260

Poly(éthylène glycol)

Expression, purification and crystallization of the herpesvirus nuclear egress complex (NEC)
Bigalke JM and Heldwein EE
Bio-protocol, 6(14), 44708-44708 (2016)
Ananthakrishnan Soundaram Jeevarathinam et al.
Biosensors & bioelectronics, 126, 831-837 (2019-01-04)
Heparin is an indispensable drug in anticoagulation therapy but with a narrow therapeutic window, which dictates regular testing and dose adjustment. However, current monitoring tools have a long turnaround time or are operator intensive. In this work, we describe a
Rapid generation of long tandem DNA repeat arrays by homologous recombination in yeast to study their function in mammalian genomes
Noskov VN, et al.
Biological Procedures Online, 13(1), 8-8 (2011)
Immunogenicity of polyethylene glycol (PEG)
The open conference proceedings journal, 2(1) (2011)
Vijay Ramani et al.
Methods (San Diego, Calif.), 170, 61-68 (2019-09-20)
The highly dynamic nature of chromosome conformation and three-dimensional (3D) genome organization leads to cell-to-cell variability in chromatin interactions within a cell population, even if the cells of the population appear to be functionally homogeneous. Hence, although Hi-C is a
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Contenu apparenté

Polyethylene Glycol (PEG) Selection Guide

Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications.

Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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