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Sigma-Aldrich

6-(4-Methoxyphenyl)-2-methyl-3,7-dihydroimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride

suitable for chemiluminescence, ≥98.0% (HPLC)

Synonyme(s) :

2-Methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride, Cypridina Luciferin methoxy-analogue, MCLA

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About This Item

Formule empirique (notation de Hill):
C14H13N3O2 · HCl
Numéro CAS:
128322-44-1
Poids moléculaire :
291.73
Numéro Beilstein :
5838857
Numéro MDL:
MFCD00144728
Code UNSPSC :
12352200
ID de substance PubChem :
57653269
Nomenclature NACRES :
NA.32

Description

luminescence test: Emmax465 nm, 0.1 M Tris pH 8.5; after addition of H2O2 (Chemiluminescence: in 0.1 M Tris pH 8.5; after addition of H2O2)

Pureté

≥98.0% (HPLC)

Forme

powder

Solubilité

DMSO: soluble
H2O: soluble

Adéquation

suitable for chemiluminescence

Chaîne SMILES 

Cl[H].COc1ccc(cc1)C2=CN3C(=O)C(C)=NC3=CN2

InChI

1S/C14H13N3O2.ClH/c1-9-14(18)17-8-12(15-7-13(17)16-9)10-3-5-11(19-2)6-4-10;/h3-8,15H,1-2H3;1H

Clé InChI

KGMPQNFFCUDXSO-UHFFFAOYSA-N

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Autres remarques

Generation of chemiluminescence by reaction with super oxide O2– or singlet oxygen. Used in research of leucocyte function.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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A Takahashi et al.
FEBS letters, 261(2), 369-372 (1990-02-26)
To investigate O2- generation in in situ lungs of rats treated with drugs to induce experimental acute respiratory distress syndrome, phorbol myristate acetate (PMA) or endotoxin were injected into rats, who had been continuously infused with 2(methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo[1,2-alpha]pyraz in-3-one (MCLA) and
Yasuhiro Kambayashi et al.
Journal of clinical biochemistry and nutrition, 41(1), 68-75 (2008-04-09)
We have proposed that diacylglycerol hydroperoxide-induced unregulated signal transduction causes oxidative stress-related diseases. In this study, we investigated which molecular species of diacylglycerol hydroperoxide activated human peripheral neutrophils. All diacylglycerol hydroperoxides, diacylglycerol hydroxides, and diacyglycerols tested in the present study
Taeko Mizutani et al.
Journal of oleo science, 65(12), 993-1001 (2016-11-11)
Sodium lauryl sulfate (SLS), a representative anionic surfactant, is well-known to induce rough skin following single or multiple topical applications. The mechanism by which SLS induces rough skin is thought to result from the disruption of skin moisture function consisting
Keiko Suzuki et al.
Antioxidants (Basel, Switzerland), 9(6) (2020-06-13)
Bisphosphonates (BPs) are classified into two groups, according to their side chain structures, as nitrogen-containing BPs (NBPs) and non-nitrogen-containing BPs (non-NBPs). In this study, we examined the effects of NBPs and non-NBPs on inflammatory responses, by quantifying the inflammatory mediators
Julia M Diaz et al.
Nature communications, 7, 13801-13801 (2016-12-08)
The reactive oxygen species superoxide (O2·-) is both beneficial and detrimental to life. Within corals, superoxide may contribute to pathogen resistance but also bleaching, the loss of essential algal symbionts. Yet, the role of superoxide in coral health and physiology
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