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19589

Sigma-Aldrich

L-2,4-Diaminobutyric acid monohydrochloride

≥98.0% (AT), ≥98.0% (TLC)

Synonyme(s) :

DAB

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About This Item

Formule empirique (notation de Hill):
C4H10N2O2 · HCl
Numéro CAS:
1482-98-0
Poids moléculaire :
154.60
Numéro Beilstein :
6086583
Numéro MDL:
MFCD01632031
Code UNSPSC :
12352200
ID de substance PubChem :
57647801

Pureté

≥98.0% (AT)
≥98.0% (TLC)

Forme

powder or crystals

Activité optique

[α]20/D +24±2°, c = 1.2% in 6 M HCl

Technique(s)

ligand binding assay: suitable

Couleur

white to off-white

Pf

≥220 °C (dec.) (lit.)

Application(s)

peptide synthesis

Chaîne SMILES 

Cl[H].NCC[C@H](N)C(O)=O

InChI

1S/C4H10N2O2.ClH/c5-2-1-3(6)4(7)8;/h3H,1-2,5-6H2,(H,7,8);1H/t3-;/m0./s1

Clé InChI

BFPDKDOFOZVSLY-DFWYDOINSA-N

Actions biochimiques/physiologiques

L-2,4-Diaminobutyric acid (DAB) is a substrate of diaminobutyrate-pyruvate transaminase (EC 2.6.1.46), an enzyme involved in an alternative polyamine biosynthesis pathway in bacteria.
L-2,4-Diaminobutyric acid (DAB, DABA), a non-metabolized amino acid, is useful as a selective GABA uptake inhibitor which may have antitumour activity against hepatoma cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Ryo Inada et al.
World journal of gastroenterology, 21(7), 2159-2168 (2015-02-27)
To analyze the mismatch repair (MMR) status and the ARID1A expression as well as their clinicopathological significance in gastric adenocarcinomas. We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric adenocarcinomas. The results were
Florence Coussy et al.
International journal of cancer, 145(7), 1902-1912 (2019-03-13)
Triple-negative breast cancer (TNBC) represents 10% of all breast cancers and is a very heterogeneous disease. Globally, women with TNBC have a poor prognosis, and the development of effective targeted therapies remains a real challenge. Patient-derived xenografts (PDX) are clinically
Mirko Manetti et al.
Journal of clinical medicine, 8(7) (2019-07-03)
Hemophilic arthropathy (HA) typically begins with proliferative synovitis that shares some similarities with inflammatory arthritides, in which the proinflammatory cytokine tumor necrosis factor (TNF)-α has a crucial pathogenetic role. Inappropriate release of TNF-α was shown to contribute to arthropathy development
Mei-Ling Chen et al.
Medicina (Kaunas, Lithuania), 55(7) (2019-07-10)
Prostate cancer (PCa) is a common malignancy in males and has a relatively slower progression than other cancers. Our goal was to evaluate the clinical role of SPARC (secreted protein acidic and cysteine rich, osteonectin), cwcv, and kazal-like domains' proteoglycan
Feng Liu et al.
Archives of gynecology and obstetrics, 300(3), 711-716 (2019-06-12)
To investigate the expression of annexin A2 (ANXA2) in ectopic and eutopic endometrium and serum of women with adenomyosis, and their relationships with adenomyosis-associated dysmenorrhea. The expression of ANXA2 was detected by immunohistochemical S-P method in ectopic and eutopic endometrium
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