PHR1366

Dibutyl phthalate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyme(s) : DBP, Phthalate de n-butyle
• Formule linéaire : C₆H₄-1,2-[CO₂(CH₂)₃CH₃]₂
• Numéro CAS: 84-74-2
• Poids moléculaire : 278.34
• Numéro Beilstein : 1914064
• Numéro CE : 201-557-4
• Numéro MDL: MFCD00009441
• Code UNSPSC : 41116107
• ID de substance PubChem : 329823345
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material; pharmaceutical secondary standard
• Niveau de qualité: 300
• Agence: traceable to Ph. Eur. D1010000; traceable to USP 1187080
• Densité de vapeur: 9.6 (vs air)
• Pression de vapeur: 1 mmHg ( 147 °C)
• Famille d'API: dibutyl phthalate
• CofA (certificat d'analyse): current certificate can be downloaded
• Température d'inflammation spontanée: 756 °F
• Limite d'explosivité: 0.47 %, 236 °F
• Conditionnement: pkg of 1 g
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Indice de réfraction: n20/D 1.492 (lit.)
• Point d'ébullition: 340 °C (lit.)
• Pf: −35 °C (lit.)
• Densité: 1.043 g/mL at 25 °C (lit.)
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Température de stockage: 2-30°C
• Chaîne SMILES: CCCCOC(=O)c1ccccc1C(=O)OCCCC
• InChI: 1S/C16H22O4/c1-3-5-11-19-15(17)13-9-7-8-10-14(13)16(18)20-12-6-4-2/h7-10H,3-6,11-12H2,1-2H3
• Clé InChI: DOIRQSBPFJWKBE-UHFFFAOYSA-N

Description

Description générale

Dibutyl Phthalate is a diester of phthalate, commonly synthesized by the condensation of the carboxy groups of phthalic acid with two molecules of 1-butanol. It is used as a plasticizer and film coating agent in solid pharmaceutical dosage forms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Dibutyl Phthalate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and dietary supplements by chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Plastifiant

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAA1470 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H360FD,H410
• Conseils de prudence: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Classification des risques: Aquatic Acute 1 - Aquatic Chronic 2 - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 339.8 °F
• Point d'éclair (°C): 171 °C