G6257
Glutaraldéhyde solution
Grade II, 25% in H2O
Synonyme(s) :
Dialdéhyde glutarique solution, Pentane-1,5-dial
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About This Item
Formule linéaire :
OHC(CH2)3CHO
Numéro CAS:
Poids moléculaire :
100.12
Numéro Beilstein :
605390
Numéro MDL:
Code UNSPSC :
12352114
ID de substance PubChem :
Nomenclature NACRES :
NA.21
Produits recommandés
Type
Grade II
Niveau de qualité
Forme
liquid
Concentration
25% in H2O
Technique(s)
electron microscopy: suitable
Couleur
colorless
Plage de pH utile
2.9
Pf
-10 °C ((14 °F ))
Solubilité
water: soluble
Application(s)
cell analysis
sample preparation
Chaîne SMILES
[H]C(CCCC([H])=O)=O
InChI
1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
Clé InChI
SXRSQZLOMIGNAQ-UHFFFAOYSA-N
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Catégories apparentées
Description générale
Glutaraldehyde, known as Glutaric dialdehyde or Pentane-1,5-dial, serves as a versatile reagent with applications spanning various research domains, including cell biology and biochemical research. It finds applications as a protein crosslinker, aids in enzyme immobilization for microscopy, and contributes to histochemistry and cytochemistry processes. As an amine-reactive homobifunctional crosslinker, it acts as a cell fixative before procedures like SDS-PAGE, staining, or electron microscopy, making it a valuable tool for diverse morphological studies.
Glutaraldehyde demonstrates efficacy in crosslinking amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it allows direct coupling of biotin hydrazides to nucleic acids, offering potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. Moreover, in histology studies, Glutaraldehyde is employed for preserving tissue sections and preparing them for detailed examination.
Glutaraldehyde demonstrates efficacy in crosslinking amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it allows direct coupling of biotin hydrazides to nucleic acids, offering potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. Moreover, in histology studies, Glutaraldehyde is employed for preserving tissue sections and preparing them for detailed examination.
Application
Glutaraldehyde solution has been used:
- for fixation of mouse and esophageal cancer cell lines
- to crosslink amyloid-β protein
- to crosslink gelatin in 3D scaffold preparation of trachea
Actions biochimiques/physiologiques
Glutaraldehyde is an effective protein crosslinker and finds application in techniques like enzyme immobilisation microscopy, histochemistry and cytochemistry. It exists in different forms under acidic or neutral conditions. It is toxic to aquatic organisms. Its allergic nature leads to hypersensitivity reactions. Contact of glutaraldehyde vapors in endoscopy contributes to Colitis.
Caractéristiques et avantages
- Versatile and adaptable for wide variety of research applications
- Ready-made solution reduces the need for preparation time
Conditionnement
Not refrigerated en route
Attention
This grade is not recommended for use as an electron microscopy fixative.
Notes préparatoires
Not specially purified.
Autres remarques
For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Clause de non-responsabilité
“The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.”
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Réf. du produit
Description
Tarif
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
Organes cibles
Respiratory system
Risques supp
Code de la classe de stockage
8A - Combustible corrosive hazardous materials
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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