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C0166000

Calcifediol

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

25-Hydroxyvitamin D3 monohydrate, 25-Hydroxycholecalciferol

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About This Item

Formule empirique (notation de Hill):
C27H44O2 · H2O
Numéro CAS:
63283-36-3
Poids moléculaire :
418.65
Numéro Beilstein :
4270041
Numéro MDL:
MFCD00867077
Code UNSPSC :
41116107
ID de substance PubChem :
329774765
Nomenclature NACRES :
NA.24

Source biologique

sheep wool (grease)

Qualité

pharmaceutical primary standard

Agence

EP

Famille d'API

calcifediol

Forme

solid

Fabricant/nom de marque

EDQM

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

Clé InChI

JWUBBDSIWDLEOM-DTOXIADCSA-N

Informations sur le gène

human ... VDR(7421)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.Calcifediol is a biologically active metabolite of vitamin D. It is more hydrophilic and better absorbed in the intestine when compared to ergocalciferol or cholecalciferol due to the high affinity for the vitamin-D-binding protein. The drug is known to treat diseases associated with decreased intestinal absorption and obesity.

Application

Calcifediol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301 + H311,H330,H372

Classification des risques

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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1α,25-dihydroxyvitamine D3 ≥99% (HPLC)

Sigma-Aldrich

D1530

1α,25-dihydroxyvitamine D3

Cholécalciférol ≥98% (HPLC)

Sigma-Aldrich

C9756

Cholécalciférol

Ergocalciferol ≥98.0% (sum of enantiomers, HPLC)

Sigma-Aldrich

95220

Ergocalciferol

Hypovitaminosis D: is it time to consider the use of calcifediol?
Cesareo R, et al.
Nutrients, 11(5), 1016-1016 (2019)
Stuart M Sprague et al.
American journal of nephrology, 40(6), 535-545 (2015-01-13)
Vitamin D insufficiency drives secondary hyperparathyroidism (SHPT) and is associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). SHPT is poorly addressed by current vitamin D repletion options. The present study evaluated a novel investigational vitamin D
Ting-I Lee et al.
International journal of cardiology, 176(1), 151-157 (2014-07-27)
High free fatty acid with reduced glucose utilization in diabetes mellitus (DM) impairs cardiac function. Peroxisome proliferator-activated receptors (PPARs) modulate myocardial lipid and glucose homeostasis. The active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates oxidative stress and inflammation, which may play a key
Johanna Breuer et al.
Annals of neurology, 75(5), 739-758 (2014-04-29)
Environmental conditions (eg, latitude) play a critical role in the susceptibility and severity of many autoimmune disorders, including multiple sclerosis (MS). Here, we investigated the mechanisms underlying the beneficial effects of immune regulatory processes induced in the skin by moderate
Kristyna Brabnikova-Maresova et al.
Arthritis research & therapy, 16(5), 460-460 (2014-10-05)
Juvenile idiopathic arthritis (JIA) is a disease associated with loss of bone mass, deterioration in bone mass quality and an increased risk of fractures. The objective of this study was to evaluate factors that predict bone mineral density (BMD) alterations
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