The solution stability has not been tested. However, literature research suggests that enrofloxacin solutions dissolved in organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO) stored under frozen conditions can typically remain stable for approximately 26 to 52 weeks (6 to 12 months). The exact stability can depend on factors such as concentration, formulation, and specific storage conditions.
17849
Enrofloxacin
≥99.0%
Synonyme(s) :
Baytril
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About This Item
Formule empirique (notation de Hill) :
C19H22FN3O3
Numéro CAS:
Poids moléculaire :
359.39
Beilstein:
5307824
Numéro MDL:
Code UNSPSC :
41116105
ID de substance PubChem :
Nomenclature NACRES :
NA.21
135,00 €
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Produits recommandés
Niveau de qualité
Essai
≥99.0%
99.0-101.0% (dried substance)
Forme
powder or crystals
Spectre d'activité de l'antibiotique
Gram-negative bacteria
Gram-positive bacteria
Mode d’action
DNA synthesis | interferes
enzyme | inhibits
Chaîne SMILES
CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4
InChI
1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)
Clé InChI
SPFYMRJSYKOXGV-UHFFFAOYSA-N
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Catégories apparentées
Description générale
Chemical structure: fluoroquinolone
Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.[1][2][3]
Application
Enrofloxacin has been used:
- to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells[1]
- to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)[2]
- as an analyte in a chemiluminescence reagent system[4]
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Is it possible to store the drug frozen for long-term preservation after dissolving it in organic solvents?
1 answer-
Helpful?
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What is the solubility of Antibiotic Question 17849 in water? This is intended for use in a mouse experiment involving drinking water.
1 answer-
The substance is not soluble in water. It has a solubility of 1mg/ml in organic solvents such as DMSO and 10 mg/ml in DMF. Additionally, it is suggested to try if the drug dissolves in (2-Hydroxypropyl)-β-cyclodextrin solution H5784.
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