06837

Benzamidine hydrochloride hydrate

• Synonyme(s) : Benzamidine hydrochloride hydrate, Amidinobenzene hydrochloride, Benzamidinium chloride, Benzenecarboximidamide hydrochloride
• Formule linéaire : C₆H₅C(=NH)NH₂ · HCl · xH₂O
• Numéro CAS: 206752-36-5
• Poids moléculaire : 156.61 (anhydrous basis)
• Numéro Beilstein : 3594959
• Numéro CE : 216-795-4
• Numéro MDL: MFCD00066285
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.21

Propriétés

• Pureté: ≥99.0% (HPLC)
• Forme: powder or crystals
• Concentration: 98.0-102.0 % (w/w) (anhydrous basis, AT); 98.0-102.0 % (w/w) (anhydrous basis, NT)
• Impuretés: ≤20 mg/kg heavy metals; ≤3000 mg/kg residual solvent (methanol) (GLC-HS); ≤5000 mg/kg residual solvents (2-propanol, acetone) (GLC-HS) (each); 8-19% water
• Pf: 86-88 °C (lit.)
• Solubilité: H₂O: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl[H].[H]O[H].NC(=N)c1ccccc1
• InChI: 1S/C7H8N2.ClH.H2O/c8-7(9)6-4-2-1-3-5-6;;/h1-5H,(H3,8,9);1H;1H2
• Clé InChI: BQVJCMMLDJPBFZ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.

In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.

Peptidase inhibitor.

Notes préparatoires

Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable