Accéder au contenu
Merck
Toutes les photos(2)

Principaux documents

ABC471

Sigma-Aldrich

Anti-KLF15 Antibody

1.0 mg/mL, from rabbit

Synonyme(s) :

Krueppel-like factor 15, Kidney-enriched krueppel-like factor, KLF15

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(2)

About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

human

Réactivité de l'espèce (prédite par homologie)

primate (based on 100% sequence homology), bat (based on 100% sequence homology), baboon (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), monkey (based on 100% sequence homology)

Concentration

1.0 mg/mL

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Numéro d'accès NCBI

NP_054798

Numéro d'accès UniProt

Q9UIH9

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... KLF15(28999)

Description générale

KLF15, also known as Krueppel-like factor 15, Kidney-enriched krueppel-like factor, and encoded by the gene KLF15/KKLF, is a transcriptional regulator that affects expression in a wide variety of developmental and cellular systems. These include glial cell differentiation, cardiac circadian expression regulation, podocyte differentiation, glomerular visceral epithelial cell differentiation, glucose transport, and negative regulation of Peptidyl-lysine acetylation. KLF15 is highly expressed in liver, skeletal muscle, cardiomyocytes and kidney cells. KLF15 is a biomarker in patients with non-ischemic cardiomyopathy, glomerular disease, and aortic aneurysm. In such patients KLF15 expression is severely down regulated. KLF15 deficiency affects the cardiac rhythm and may play a role in ventricular arrhythmias and pathological conditions of the heart.

Immunogène

Epitope: Unknown
KLH-conjugated linear peptide corresponding to human KLF15.

Application

Anti-KLF15 Antibody detects level of KLF15 & has been published & validated for use in KLF15.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected KLF15 in human liver tissue.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

Qualité

Evaluated by Western Blotting in human skeletal muscle tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected KLF15 in 10 µg of human skeletal muscle tissue lysate.

Description de la cible

~46 kDa observed

Forme physique

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Vous ne trouvez pas le bon produit ?  

Essayez notre Outil de sélection de produits.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Yue-Tong Guo et al.
Journal of the American Heart Association, 10(16), e020554-e020554 (2021-08-06)
Background Adventitial remodeling is a pathological hallmark of hypertension that results in target organ damage. Activated adventitial fibroblasts have emerged as critical regulators in this process, but the precise mechanism remains unclear. Methods and Results Interleukin 11 (IL-11) knockout and
Xiangchen Gu et al.
Kidney international, 92(5), 1178-1193 (2017-06-28)
Large epidemiological studies clearly demonstrate that multiple episodes of acute kidney injury contribute to the development and progression of kidney fibrosis. Although our understanding of kidney fibrosis has improved in the past two decades, we have limited therapeutic strategies to
Yiqing Guo et al.
Journal of the American Society of Nephrology : JASN, 29(10), 2529-2545 (2018-08-26)
Podocyte injury is the hallmark of proteinuric kidney diseases, such as FSGS and minimal change disease, and destabilization of the podocyte's actin cytoskeleton contributes to podocyte dysfunction in many of these conditions. Although agents, such as glucocorticoids and cyclosporin, stabilize

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique