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AB1426

Sigma-Aldrich

Anti-Uncoupling Protein 1 Antibody

Chemicon®, from rabbit

Synonyme(s) :

UCP1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

human, rat, mouse

Fabricant/nom de marque

Chemicon®

Technique(s)

ELISA: suitable
western blot: suitable

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... UCP1(7350)

Spécificité

Reactive with mouse, rat, and human UCP1. Reactivity confirmed by western blot of purified UCP from brown adipose tissue. No cross-reactivity with UCP2.

Immunogène

Synthetic peptide corresponding to amino acids 145-159 of mouse UCP1. (C)SHLHGIKPRYTGTYN

Application

ELISA: 1:100,000

Western blot: 1:1,000

Optimal working dilutions must be determined by the end user.
Research Category
Metabolism
Research Sub Category
Ion & Transport Channels
This Anti-Uncoupling Protein 1 Antibody is validated for use in ELISA, WB for the detection of Uncoupling Protein 1.

Forme physique

Format: Purified
Protein A-purified rabbit immunoglobulin. Liquid. Buffer = 100 mM KHPO4, 140 mM NaCl, pH 7. Contains no preservatives.

Stockage et stabilité

Maintain at -20 in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Kana Oue et al.
The Journal of biological chemistry, 291(8), 4185-4196 (2015-12-27)
Phospholipase C-related catalytically inactive protein (PRIP) was first identified as an inositol 1,4,5-trisphosphate-binding protein, and was later found to be involved in a variety of cellular events, particularly those related to protein phosphatases. We previously reported that Prip knock-out (KO)
Han Fang et al.
iScience, 24(5), 102470-102470 (2021-06-12)
Dietary methionine restriction (MR) is normally implemented using diets formulated from elemental amino acids (AA) that reduce methionine content to ∼0.17%. However, translational implementation of MR with elemental AA-based diets is intractable due to poor palatability. To solve this problem
Hongyi Zhou et al.
Journal of lipid research, 56(10), 1912-1925 (2015-08-14)
Mutations in BSCL2/SEIPIN cause Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), but the mechanisms whereby Bscl2 regulates adipose tissue function are unclear. Here, we generated adipose tissue (mature) Bscl2 knockout (Ad-mKO) mice, in which Bscl2 was specifically ablated in adipocytes of
Julio Sevillano et al.
Diabetologia, 62(1), 123-135 (2018-10-18)
Pleiotrophin, a developmentally regulated and highly conserved cytokine, exerts different functions including regulation of cell growth and survival. Here, we hypothesise that this cytokine can play a regulatory role in glucose and lipid homeostasis. To test this hypothesis, we performed
Hwan Hee Lee et al.
Nature communications, 10(1), 3536-3536 (2019-08-08)
Tonicity-responsive enhancer binding protein (TonEBP or NFAT5) is a regulator of cellular adaptation to hypertonicity, macrophage activation and T-cell development. Here we report that TonEBP is an epigenetic regulator of thermogenesis and obesity. In mouse subcutaneous adipocytes, TonEBP expression increases > 50-fold

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