454575

N-Methyl-D-aspartic Acid hydrate

>95% (TLC), solid, excitatory amino acid neurotransmitter, Calbiochem^®

• Synonyme(s) : N-Methyl-D-aspartic Acid, Hydrate, NMDA
• Formule empirique (notation de Hill) : C₅H₉NO₄ · xH₂O
• Numéro CAS: 6384-92-5
• Poids moléculaire : 147.13 (anhydrous basis)
• Numéro MDL: MFCD00004226
• Code UNSPSC : 12352209
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: N-Methyl-D-aspartic Acid, Hydrate, Excitatory amino acid neurotransmitter.
• Niveau de qualité: 100
• Description: Merck USA index - 14, 6662
• Essai: >95% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: water: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• Chaîne SMILES: N([C@H](CC(=O)O)C(=O)[O-])C
• InChI: 1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
• Clé InChI: HOKKHZGPKSLGJE-GSVOUGTGSA-M

Description

Description générale

An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Glutamate receptor that regulates Ca2+ channels

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for several days at 4°C.

Autres remarques

Mattson, M.P., et al. 1993. J. Neurosci. 13, 4575.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable