700052P
Avanti
22(R)-hydroxycholesterol-d7
Avanti Research™ - A Croda Brand
Synonyme(s) :
25,26,26,26,27,27,27-heptadeuterocholest-5-ene-3β,22R-diol
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About This Item
Formule empirique (notation de Hill):
C27H39O2D7
Numéro CAS:
Poids moléculaire :
409.70
Code UNSPSC :
41141804
Nomenclature NACRES :
NA.25
Produits recommandés
Description
cholest-5-ene-3β,22(R)-diol-d7
Pureté
>99% (TLC)
Forme
powder
Conditionnement
pkg of 1 × 1 mg (700052P-1mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand
Application(s)
lipidomics
metabolomics
Conditions d'expédition
dry ice
Température de stockage
−20°C
Description générale
22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in the neonate brain. 22(R)-hydroxycholesterol-d7 is a deuterated form of 22(R)-hydroxycholesterol.
Actions biochimiques/physiologiques
22(R)-hydroxycholesterol (22(R)-HC) is a liver X receptor (LXR) ligand and is a key for the receptor activation.. 22(R)-HC promotes mesenchymal stem cell osteogenesis along with other oxysterols. It also regulates cholesterol homeostasis and suppresses prostate tumor progression. Low levels of 22(R)-HC is observed in Alzheimer′s disease and may be implicated in neuroinflammation and neurodegenerative diseases.
Conditionnement
5 mL Amber Glass Screw Cap Vial (700052P-1mg)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Code de la classe de stockage
11 - Combustible Solids
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Megan M Augustin et al.
The Plant journal : for cell and molecular biology, 82(6), 991-1003 (2015-05-06)
Steroid alkaloids have been shown to elicit a wide range of pharmacological effects that include anticancer and antifungal activities. Understanding the biosynthesis of these molecules is essential to bioengineering for sustainable production. Herein, we investigate the biosynthetic pathway to cyclopamine
Combined treatment with 9-cis beta-carotene and 22R-hydroxycholesterol augments cholesterol efflux in macrophages
Mahler L, et al.
Algal research, 44, 101700-101700 (2019)
Hyunmi Kim et al.
Biochimica et biophysica acta, 1859(8), 1056-1070 (2016-05-22)
MAP kinase phosphatase (MKP)-1 plays a pivotal role in controlling MAP kinase (MAPK)-dependent (patho) physiological processes. Although MKP-1 gene expression is tightly regulated at multiple levels, the underlying mechanistic details remain largely unknown. In this study, we demonstrate that MKP-1
Jin-Sun Lee et al.
Stem cell research & therapy, 8(1), 276-276 (2017-12-07)
Oxysterols, oxygenated by-products of cholesterol biosynthesis, play roles in various physiological and pathological systems. However, the effects of oxysterols on periodontal regeneration are unknown. This study investigated the effects of the specific oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol (SS) on
Chih-Pin Chuu et al.
Anticancer research, 30(9), 3643-3648 (2010-10-15)
Previously, we and other groups reported that liver X receptor (LXR) agonists T0901317, 22(R)-hydroxycholesterol, and 24(S)-hydroxycholesterol suppressed the proliferation of prostate and breast cancer cells. In this study, we report that T0901317 and 22(R)-hydroxycholesterol treatment inhibited the proliferation of different
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