Accéder au contenu
Merck
Toutes les photos(2)

Principaux documents

Voir toute la documentation

700040P

Avanti

desmosterol-d6

Avanti Research™ - A Croda Brand

Synonyme(s) :

24-dehydrocholesterol(d6); 5,24-cholestadien-3β-ol(d6)

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

Sélectionner une taille de conditionnement

1 MG
382,00 €

382,00 €

Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
Devis pour commande en gros
Toutes les photos(2)

Sélectionner une taille de conditionnement

Changer de vue
1 MG
382,00 €

About This Item

Formule empirique (notation de Hill) :
C27H38OD6
Numéro CAS:
1246298-67-8
Poids moléculaire :
390.67
Numéro MDL:
MFCD00010474
Code UNSPSC :
12352100
Nomenclature NACRES :
NA.25

382,00 €

Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
Devis pour commande en gros

Description

cholesta-5,24-dien-3β-ol-d6

Essai

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 1 mg (700040P-1mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand

Conditions d'expédition

dry ice

Température de stockage

−20°C

Description générale

Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24).[1] It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway.[2] Desmosterol-d6 is a deuterated form of desmosterol.

Application

Desmosterol-d6 has been used:
  • as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)[3]
  • as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)[4]
  • for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis[5]

Actions biochimiques/physiologiques

Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons.[1] Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication.[2] Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.[5]

Conditionnement

5 mL Amber Glass Screw Cap Vial (700040P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Souvent commandé avec ce produit

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

Si vous avez besoin d'assistance, veuillez contacter Service Clients

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Valerie A Villareal et al.
ACS chemical biology, 11(7), 1827-1833 (2016-04-30)
Hepatitis C virus (HCV) increases intracellular desmosterol without affecting the steady-state abundance of other sterols, and the antiviral activity of inhibitors of desmosterol synthesis is suppressed by the addition of exogenous desmosterol. These observations suggest a model in which desmosterol
Yoshiaki Sato et al.
Alzheimer's & dementia (Amsterdam, Netherlands), 1(1), 67-74 (2015-03-01)
We here examined whether plasma desmosterol-to-cholesterol ratio (DES/CHO) is decreased in patients with Alzheimer's disease (AD) and investigated the association between plasma DES/CHO and longitudinal cognitive decline. Plasma DES/CHO of AD patients and age-matched controls in a Japanese cross-sectional cohort
Thomas Wisniewski et al.
Journal of Alzheimer's disease : JAD, 33(3), 881-888 (2012-10-09)
Desmosterol is a C27 sterol intermediate in cholesterol synthesis generated during the metabolic pathway that transforms lanosterol into cholesterol. It has become of particular interest in the pathogenesis of Alzheimer's disease (AD) because of the report that the activity of
Jeffrey G McDonald et al.
Methods in enzymology, 432, 145-170 (2007-10-24)
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues. Bulk lipids are extracted from biological samples by a modified Bligh/Dyer procedure in
Priyadarshini Chakrabarti et al.
Metabolomics : Official journal of the Metabolomic Society, 15(10), 127-127 (2019-09-21)
Significant annual honey bee colony losses have been reported in the USA and across the world over the past years. Malnutrition is one among several causative factors for such declines. Optimal nutrition serves as the first line of defense against

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique