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KITALYSIS-CN

Sigma-Aldrich

KitAlysis™ High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

Synonyme(s) :

Amination Screening Kit, Buchwald-Hartwig Amination

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About This Item

Code UNSPSC :
12161503
Nomenclature NACRES :
NA.22

Capacité de réaction

reaction type: Buchwald-Hartwig Amination
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings

Pertinence de la réaction

reagent type: catalyst
core: palladium

Température de stockage

room temp

Catégories apparentées

Description générale

The KitAlysis™ High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.

Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here

Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains



  • 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
  • 2 bases (NaOt-Bu and Cs2CO3)
  • 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
  • 2 substrate reaction vials with stir bars
  • 1 internal standard
  • 4 reaction block replacement films
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Caractéristiques et avantages

  • Designed and tested by synthetic chemists
  • Easily run 24-microscale reaction in parallel
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Informations légales

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Composants de kit seuls

Réf. du produit
Description
  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Composants de kit également disponibles séparément

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Description
FDS
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En option

Réf. du produit
Description
Tarif

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3

Organes cibles

Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system

Risques supp

EUH019

Code de la classe de stockage

4.2 - Pyrophoric and self-heating hazardous materials

Point d'éclair (°F)

-4.0 °F - closed cup

Point d'éclair (°C)

-20 °C - closed cup

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Protocoles

Two solvents (Dioxane, DMAc), weak base (Cs2CO3) Step-by-Step Guide for Buchwald-Hartwig Amination Screening Kit

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.

Two solvents (Dioxane, DMAc), Strong Base (NaOt-Bu) Step-by-Step Guide for Buchwald-Hartwig Amination Reaction Screening Kit

Protocol for the KitAlysis™ Buchwald-Hartwig Amination Reaction Screening Kit

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Contenu apparenté

One Solvent (Dioxane), two bases (NaOtBu, Cs2CO3) Step-by-Step Guide for Buchwald-Hartwig Amination Reaction Screening Kit

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.

Conception et optimisation de réactions

La conception et l'optimisation d'une réaction chimique en synthèse organique vise à altérer avec précision certains paramètres de la réaction pour obtenir des résultats optimaux dans la recherche de voies menant aux molécules cibles.

Reaction Design & Optimization

Chemical reaction design and optimization in organic synthesis aims to precisely alter reaction parameters to achieve optimum results in finding pathways to target molecules.

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