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Merck
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935433

Sigma-Aldrich

Heparin methacrylate (HepMA)

Synonyme(s) :

3D bioprinting, Bioprinting, HepMA, Heparin, Heparin methacrylate, Hydrogel

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About This Item

Code UNSPSC :
12162002
Nomenclature NACRES :
NA.21

Description

Degree of functionalization: 10-30% methacrylation

Niveau de qualité

100

Forme

powder or chunks (or fibers)

Couleur

white to off-white

Température de stockage

2-8°C

Catégories apparentées

Description générale

Heparin methacrylate (HepMa) is a functionalized natural polymer that can be used in 3D bioprinting and tissue engineering applications.

Heparin is a naturally occurring linear biopolymer and highly sulfated glycosaminoglycan (GAG). Research has demonstrated that heparin can modulate binding extracellular matrix proteins and sequester growth factors and cytokines, making them useful in 3D applications. The methacrylate-functionalization of heparin allows thermal or photochemical crosslinking via covalent conjugation. Heparins exhibit high anionic charge densities to promote large swelling ratios in water.

Application

Heparin based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug delivery applications.

Caractéristiques et avantages

  • Batch control offers reproducible models for preclinical toxicology testing and drug screening
  • Extended shelf-life & stability

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Anastasia Nilasaroya et al.
Biomaterials, 29(35), 4658-4664 (2008-09-19)
Synthetic scaffolds show great promise for use in tissue engineering due to their ability to mimic some aspects of the extracellular matrix, however, their use has been hindered by the lack of inherent recognition sites that are required for protein
Hangjun Ding et al.
ACS nano, 8(5), 4348-4357 (2014-04-18)
The emergence of flexible and stretchable electronic components expands the range of applications of electronic devices. Flexible devices are ideally suited for electronic biointerfaces because of mechanically permissive structures that conform to curvilinear structures found in native tissue. Most electronic
Danielle S W Benoit et al.
Biomaterials, 28(1), 66-77 (2006-09-12)
Poly(ethylene glycol) (PEG) hydrogels functionalized with heparin were utilized as a three-dimensional culture system for human mesenchymal stem cells (hMSCs). Heparin-functionalized hydrogels supported hMSC viability, as quantified through live/dead imaging, and induced osteogenic differentiation, as measured by increased alkaline phosphatase

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