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901398

Sigma-Aldrich

Polyester bis-MPA dendron

no. Surface Groups 8, carboxyl, 1 NHBoc (core), generation 3

Synonyme(s) :

Bis-MPA dendron, PFd-G3-BocNH-COOH

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About This Item

Formule empirique (notation de Hill) :
C83H119NO53
Poids moléculaire :
1978.81
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Forme

solid

Poids mol.

generation 3

Nb de groupes de surface

8

Couleur

white to off-white

Température de stockage

−20°C

Description générale

  • Polymer architecture: Dendron
  • Generation: 3
  • Core functional group: Boc-protected amine
  • End group functionality: Carboxylic acid
  • No. surface groups: 8
  • Calculated mol. wt.: 1978.82 g/mol
  • Boc: tert-Butyloxycarbonyl
  • Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid
Polyester bis-MPA dendron (8 carboxyl, 1 NHBoc (core), generation 3), a high generation dendron, is synthesized by using anhydride activated bis-MPA monomers via divergent growth. It has a large and exact number of reactive groups and has dual functionalization capacity that makes it useful as a high-value scaffold.[1][2]

Application

Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. Both the carboxylic acid-functionalized dendrimers and amine-functionalized (after Boc deprotection) core can be readily used in EDC or DCC coupling reactions with amine or carbonyl-containing compounds, respectively, to yield highly functionalized materials for a variety of biomedical applications.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
MKCT1673
MKCG5773

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Rapid Synthesis of Functionalized High-Generation Polyester Dendrimers via Strain-Promoted Alkyne-Azide Cycloaddition
McNelles SA and Adronov Al
Macromolecules, 50(20), 7993-8001 (2017)
Fluoride-promoted esterification (FPE) chemistry: A robust route to Bis-MPA dendrons and their postfunctionalization
Stenstrom P, et al.
Molecules (Basel), 21(3), 366-366 (2016)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articles

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

New Multi-Dendrimer Platforms for Supramolecular Assembly

Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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