Biocompatible, amphiphilic triblock polymer composed of a hydrophilic, central PEG block and two terminal hydrophobic PCL blocks. These materials have been used in drug delivery applications as well as thermoplastic elastomers. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
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Poly(caprolactone)-poly(ethylene glycol)-poly(caprolactone) (PCL-PEG-PCL) nanoparticles: a valuable and efficient system for in vitro and in vivo delivery of curcumin.
Manjili HK, et al.
Royal Society of Chemistry Advances, 6, 14403-14415 (2016)
Synthesis and microphase separation of biodegradable poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) multiblock copolymer films.
You JH, et al.
Macromolecular Research, 16(7), 609-613 (2008)
Synthesis and Characterization of PEG-PCL-PEG Triblock Copolymers as Carriers of Doxorubicin for the Treatment of Breast Cancer.
Cuong NV, et al.
Journal of Applied Polymer Science, 117, 3694-3703 (2010)
International journal of pharmaceutics, 365(1-2), 89-99 (2008-09-17)
In this work, a series of biodegradable triblock poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) copolymers were successfully synthesized by ring-opening copolymerization, and were characterized by (1)H NMR, FT-IR, GPC, and DSC. Aqueous solutions of PECE copolymers underwent thermosensitive sol-gel-sol transition as
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