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Merck

DDC

dopa decarboxylase (aromatic L-amino acid decarboxylase)

Synonymes:
AADC
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(1644) Summary: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
  • Mouse(13195) dopa decarboxylase
  • Rat(24311) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • Zebrafish(406651) dopa decarboxylase
  • fruit fly(35190) Dopa decarboxylase
  • chicken(420947) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • dog(606852) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • domestic cat(101082989) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • cow(280762) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • Horse(100052557) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • sheep(101106765) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • naked mole-rat(101697555) dopa decarboxylase (aromatic L-amino acid decarboxylase)
  • domestic guinea pig(100135516) dopa decarboxylase

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-DDC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-DDC antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL2962, purified immunoglobulin, buffered aqueous glycerol solution,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
Anti-DDC antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
guinea pig, human, mouse, rat
Application
western blot
Anti-Dopa Decarboxylase Antibody, Chemicon®, from rabbit,
Espèces réactives
canine, human, sheep
Application
western blot
Anti-DDC antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
Benserazide hydrochloride, ≥98% (HPLC), solid,
Espèce(s)
human
Carbidopa, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
S-(−)-Carbidopa, ≥98% (TLC), powder,
Espèce(s)
human
Benserazide for peak identification A, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Carbidopa, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Ddc,
Espèce(s)
mouse