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Key Documents

SRP2104

Sigma-Aldrich

Arginine Splicing Factor, His tagged human

recombinant, expressed in insect cells, ≥85% (SDS-PAGE)

Synonym(s):

ASF, FLJ53078, MGC5228, SF2, SF2p33, SFRS1, SRp30a

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5 μG
€580.00

€580.00

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5 μG
€580.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.26

€580.00

Please contact Customer Service for Availability

biological source

human

recombinant

expressed in insect cells

Assay

≥85% (SDS-PAGE)

form

frozen liquid

mol wt

~29.3 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

350 μg/mL

color

clear
 colorless

NCBI accession no.

NM_006924

UniProt accession no.

Q07955

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... SRSF1(6426)

Biochem/physiol Actions

ASF also known as SF2 is a member of the SR protein family. It is an essential pre-mRNA splicing factor required for both single and alternative splicing. Phosphorylation on serine residues located within the SR domain directly regulates ASF/SF2 activity and compartmentalization of other SR splicing factors. In addition to interacting with RNA and other splicing factors, such as U1-70K, U2AF and other SR proteins, ASF/SF2 also directly or indirectly interacts with HIV regulatory protein Rev, the C-terminal domain (CTD) of the largest subunit of RNA polymerase II, and numerous transcription factors, thereby suggesting a potential role of ASF/SF2 in coordinating transcription and pre-mRNA splicing.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
128227015

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H Ge et al.
Cell, 62(1), 25-34 (1990-07-13)
SV40 early pre-mRNA is alternatively spliced by utilization of two different 5' splice sites and a shared 3' splice site to produce large T and small t mRNAs. The ratio of small t to large T mRNAs produced in human
A R Krainer et al.
Cell, 66(2), 383-394 (1991-07-26)
SF2 is a protein factor essential for constitutive pre-mRNA splicing in HeLa cell extracts and also activates proximal alternative 5' splice sites in a concentration-dependent manner. This latter property suggests a role for SF2 in preventing exon skipping, ensuring the
A M Zahler et al.
Genes & development, 6(5), 837-847 (1992-05-01)
We demonstrate that four different proteins from calf thymus are able to restore splicing in the same splicing-deficient extract using several different pre-mRNA substrates. These proteins are members of a conserved family of proteins recognized by a monoclonal antibody that

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