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Key Documents

SML3662

Sigma-Aldrich

Etrasimod arginine

≥98% (HPLC)

Synonym(s):

APD 334 L-Arginine, L-Arginine mono[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopent[b]indol-3-yl]acetate, L-Arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid

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5 MG
€173.00
25 MG
€695.00

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5 MG
€173.00
25 MG
€695.00

About This Item

Empirical Formula (Hill Notation):
C32H40F3N5O5
CAS Number:
Molecular Weight:
631.69
UNSPSC Code:
12352209
UNSPSC Code:
12352200
NACRES:
NA.25

€173.00


Availability
Please contact Customer Service for Availability

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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

N[C@@H](CCCNC(N)=N)C(O)=O.O=C(O)C[C@H]1CCC2=C1NC3=C2C=C(OCC4=CC=C(C5CCCC5)C(C(F)(F)F)=C4)C=C3

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This Item
C8022M7033SML1461
assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

100

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

methanol: 20 mg/mL, clear, colorless to faintly yellow

solubility

water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

H2O: 20 mg/mL, clear

color

white to beige

color

-

color

-

color

white to beige

Biochem/physiol Actions

Etrasimod arginine is an orally available, potent, and selective agonist of Sphingosine-1-Phosphate Receptors 1 (S1PR1). Also, it acts as a partial agonist of S1PR4,5. Etrasimod arginine induces reductions in lymphocyte counts in mice. It is acting as immunosuppressive agents.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Arianna Dal Buono et al.
    Biomedicines, 10(7) (2022-07-28)
    Inflammatory bowel diseases (IBDs) are chronic and disabling conditions that, uncontrolled, lead to irreversible bowel damage and associated comorbidities. Despite the new era of biological therapies, IBDs remain not curative. The treatment purpose is to induce endoscopic remission, reduce the
    Hussien Al-Shamma et al.
    The Journal of pharmacology and experimental therapeutics, 369(3), 311-317 (2019-03-16)
    Lymphocyte trafficking out of secondary lymphoid organs is regulated by concentration gradient-dependent interactions between the membrane-derived lysophospholipid signaling molecule sphingosine 1-phosphate (S1P) and the G-protein-coupled receptor, S1P1 Etrasimod is a novel, next-generation, small-molecule, oral S1P receptor modulator in clinical development
    Matej Zore et al.
    Frontiers in microbiology, 13, 926170-926170 (2022-06-24)
    New classes of antibiotics are urgently needed in the fight against multidrug-resistant bacteria. Drug repurposing has emerged as an alternative approach to accelerate antimicrobial research and development. In this study, we screened a library of sphingosine-1-phosphate receptor (S1PR) modulators against

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