810155P
Avanti
18:1-06:0 NBD PE
Avanti Research™ - A Croda Brand
Synonym(s):
1-oleoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphoethanolamine
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About This Item
Empirical Formula (Hill Notation):
C35H58N5O11P
CAS Number:
Molecular Weight:
755.84
UNSPSC Code:
12352211
NACRES:
NA.25
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (810155P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
General description
N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) phosphoethanolamine (NBD PE) is a fluorescently labelled lipid with NBD attached to phosphatidylethanolamine. It is localized at the membrane interface. Phosphoethanolamine is the second most abundant, metabolically related aminophospholipid and is mostly enriched in brain.
Application
18:1-06:0 NBD PE may be used to analyse the temporal fluorescent pattern of cholesterol-E- Nitrobenzoxadiazole (Chol-E-NBD).
Biochem/physiol Actions
N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) phosphoethanolamine (NBD PE) is used as a fluorescent analog in the studies of organization and dynamics of membranes. Phosphoethanolamine (PE) functions as a substrate for a number of phospholipids of the cell membrane.
Packaging
5 mL Amber Glass Screw Cap Vial (810155P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Synthetic phosphoethanolamine induces cell cycle arrest and apoptosis in human breast cancer MCF-7 cells through the mitochondrial pathway
Ferreira AK, et al.
Biomedicine & Preventive Nutrition, 67(6), 481-487 (2013)
Fluorescent methods to study biological membranes, 37-50 (2012)
Cardiolipin and phosphatidylethanolamine role in dibucaine interaction with the mitochondrial membrane
Lopes SC, et al.
Biochim. Biophys. Acta Gen. Subj., 1861(6), 1152-1161 (2019)
Synthesis and validation of novel cholesterol-based fluorescent lipids designed to observe the cellular trafficking of cationic liposomes
Kim BK, et al.
Bioorganic & Medicinal Chemistry, 25(18), 3893-3896 (2015)
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
Vance JE and Tasseva G
Biochim. Biophys. Acta Gen. Subj., 1831(3), 543-554 (2013)
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