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Get in the Fast Lane – Vital Products at Starting Line

A curated selection of essential biotech technologies and expert advice to start your process development

Accelerate your path to the patient with a curated set of technologies and expert counsel

Whether you are in the early stages of developing monoclonal antibodies, cell therapies, or gene therapies, you need to establish a robust and scalable GMP production process.

Selecting the right technologies is essential but can be time-consuming and resource-intensive with so many choices and variables to consider. Choose the right solutions at the starting line and you’ll establish a workflow that positions you for long-term success, reduces risk, and accelerates progress towards your most important milestones.

Get a headstart! Talk to our team of experts today.

We invite you to explore these proven upstream, downstream, and final fill/formulation manufacturing technologies and then connect with our experts to tailor the perfect set for your specific process requirements.

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Gene Therapies Technologies & Solutions

Gene therapy offers tremendous potential to treat and cure countless diseases for which there is a high unmet need. And require critical speed to market to meet patient needs.

While development and production require speed and agility, gene therapies are manufactured without any templated approach, under evolving regulatory guidelines, and in many cases, for small patient populations.

Process efficiency, scalability, and high costs are just a few of the challenges facing the industry as innovators seek to maximize productivity, purity, and yield.

Explore our technologies, products, and services design to overcome these challenges and support the gene therapy manufacturing workflow from process development to commercial-scale productions. 

Take the first step today! Talk to our team of experts.

Illustration of an adeno-associated virus

AAV Vector Production

Adeno-associated viruses (AAV) are an important component of many in vivo gene therapies, where they deliver essential genetic material to various cells and tissues.

Find the products we recommend to start your AAV process development. 

StepProductCatalogue number
UpstreamSf-RVN™ Insect Cell LineSFRVN
VirusExpress® 293 AAV Production CellsVP002
EX-CELL® CD Insect Cell Medium14380C-1000ML
EX-CELL® CD HEK293 Viral Vector Medium14385C-10B
Cellvento® 4HEK Liquid1251931000
Mobius® Power MIX 100L MXRJ100TLA
Mobius® Power MIX 200L MXRJ200TA
Millipore Express® SHRP, OptiScale® Capsule, filtration area 3.5 cm2, OptiScale® 25, pore size 0.5/0.1 μmSHVEA25NB6
Millipore Express® SHR, OptiScale® Capsule, filtration area 3.5 cm2, OptiScale® 25SVEPA25NB6
Millipore Express® SHRP, OptiScale® Capsule, OptiScale® 47, filtration area 17.7 cm2, pore size 0.5/0.1 μmSHVEA47FF3
Millipore Express® SHRP, OptiScale® Capsule, filtration area 17.7 cm2, OptiScale® 47, pore size 0.5/0.1 μmSHVEA47FH3
Millipore Express® SHR, OptiScale® Capsule, OptiScale® 47SVEPA47FH3
Millipore Express® SHRP, OptiScale® Capsule, filtration area 17.7 cm2, OptiScale® 47, pore size 0.5/0.1 μmSHVEA47HH3
Millipore Express® SHR, OptiScale® Capsule, OptiScale® 47SVEPA47FF3
CellPrime® r LR3 IGF liquid1063320005
Poloxamer 188 EMPROVE® EXPERT compendial cell culture grade137197
Single-use 3L stirred tank bioreactor (green)CR0003L200
Benzonase® endonuclease Safety Plus, EMPROVE® EXPERT1037731010
 Benzonase® Salt Tolerant Endonuclease1.04445
ClarificationMillistak+® HC Pro Pod Depth Filter, C0SP, filtration area 23 cm2, hydrophilicMC0SP23CL3
Bioburden Reduction/Sterilizing-gradeMillipore Express® SHC, OptiScale® Capsule, OptiScale® 25, filtration area 3.5 cm2, pore size 0.5/0.2 μmSHGEA25NB6
Anion ExchangeEshmuno® Q Resin, MiniChrom Column Eshmuno® Q, volume 1 mL, prepacked column1250650001
Fractogel® EMD TMAE Hicap (M), MiniChrom Column Fractogel® TMAE Hicap (M), volume 1 mL, prepacked column1250570001
Fractogel® EMD TMAE Hicap (M), MiniChrom Column Fractogel® TMAE Hicap (M), volume 5 mL, prepacked column1250710001
Cation ExchangeFractogel® EMD SO3 ⁻ (M) Resin, MiniChrom Column Fractogel® SO3 (M), volume 1 mL, prepacked column1250610001
Fractogel® EMD SO3 ⁻ (M) Resin, MiniChrom Column Fractogel® SO3 (M), volume 5 mL, prepacked column1250720001
Virus FiltrationOptiscale® 25 Viresolve® NFPSZRV025NB9
Final FiltrationDurapore® 0.22 µm, OptiScale® Capsule, OptiScale® 25, filtration area 3.5 cm2SVGLA25NB6

Interested into our full capabilities for your AAV process? Browse the Biopharmaceutical Application Guide  to help you find the right products and services for your needs.

 

Illustration of a lentiviral vector

Lentivirus Production

Lentiviral vectors are primarily used in ex vivo gene therapy to transport new genetic material into cells cultured outside of the body, which are then administered to the patient.

Step
ProductCatalogue number
UpstreamVirusExpress® 293T Lentiviral Production CellsVP001-1VL
EX-CELL® CD HEK293 Viral Vector Medium14385C-10B
Mobius® Power MIX 100L MXRJ100TLA
Mobius® Power MIX 200L MXRJ200TA
Millipore Express® SHRP, OptiScale® Capsule, filtration area 3.5 cm2, OptiScale® 25, pore size 0.5/0.1 μmSHVEA25NB6
Millipore Express® SHR, OptiScale® Capsule, filtration area 3.5 cm2, OptiScale® 25SVEPA25NB6
Millipore Express® SHRP, OptiScale® Capsule, OptiScale® 47, filtration area 17.7 cm2, pore size 0.5/0.1 μmSHVEA47FF3
Millipore Express® SHRP, OptiScale® Capsule, filtration area 17.7 cm2, OptiScale® 47, pore size 0.5/0.1 μmSHVEA47FH3
Millipore Express® SHR, OptiScale® Capsule, OptiScale® 47SVEPA47FH3
Millipore Express® SHRP, OptiScale® Capsule, filtration area 17.7 cm2, OptiScale® 47, pore size 0.5/0.1 μmSHVEA47HH3
Millipore Express® SHR, OptiScale® Capsule, OptiScale® 47SVEPA47FF3
CellPrime® r LR3 IGF liquid106332
Poloxamer 188 EMPROVE® EXPERT compendial cell culture grade137197
Single-use 3L stirred tank bioreactor (green)CR0003L200
Benzonase® Salt Tolerant Endonuclease1.04445
Benzonase® endonuclease Safety Plus, EMPROVE® EXPERT1037731010
ClarificationMillistak+® Depth Filter in μPOD formatMCE5023CL3
Bioburden Reduction/Sterilizing-grade

Durapore® 0.45 µm, OptiScale® Capsule,
OptiScale® 25, filtration area 3.5 cm2		SPHLA25NB6
Concentration/DiafiltrationPellicon® XL Cassette with Ultracel® Membrane, filtration area 50 cm2PXC300C50
Anion ExchangeFractogel® EMD DEAE (M), MiniChrom Fractogel® DEAE (M), volume 1 mL, prepacked column1250580001
Natrix® Q MicroNXF-01
Eshmuno® Q Resin, MiniChrom Column Eshmuno® Q, volume 1 mL, prepacked column1250650001
Eshmuno® Q Resin, MiniChrom Column Eshmuno® Q, volume 5 mL, prepacked column1250740001
Final FiltrationDurapore® 0.22 µm, OptiScale® Capsule, OptiScale® 25, filtration area 3.5 cm2SVGLA25NB6

Interested into our full capabilities for your Lentivirus process? Browse the Biopharmaceutical Application Guide  to help you find the right products and services for your needs.

 

Illustration of a monoclonal antibody

mAbs Production

Monoclonal antibodies (mAb) are manufactured using a templated approach that encompasses all steps in the process from cell line development to final fill.  Despite the process being templated, robust and scalable solutions are essential to meet productivity, yield, and purity objectives. Additional initiatives include increasing upstream bioreactor titers, formulating high therapeutic concentrations, and adopting continuous processes.

Explore our technologies, products and services that support your mAb programs from process development to commercial scale and help deliver on your productivity objectives and initiatives.

StepProductCatalogue number
UpstreamCHOZN® ZFN-Modified CHO Cell LineCHOGS
Cell Culture Media 4CHO Sample Kit1038820001
Single-use 3L stirred tank bioreactor (green)CR0003L200
ClarificationMillistak+® HC Pro Pod Depth Filter, D0SP, filtration area 23 cm2, hydrophilicMD0SP23CL3
Millistak+® HC Pro Pod Depth Filter, X0SP, filtration area 23 cm2, hydrophilicMX0SP23CL3
Bioburden Reduction/Sterilizing-gradeMillipore Express® SHC, OptiScale® Capsule, OptiScale® 25, filtration area 3.5 cm2, pore size 0.5/0.2 μmSHGEA25NB6
Protein AEshmuno® A Resin, MiniChrom Column Eshmuno® A, volume 5 mL, prepacked column1251610001
Anion ExchangeNatrix® Q MicroNXF-01
Eshmuno® Q Resin, MiniChrom Column Eshmuno® Q, volume 1 mL, prepacked column1250650001
Eshmuno® Q Resin, MiniChrom Column Eshmuno® Q, volume 5 mL, prepacked column1250740001
Fractogel® EMD TMAE Hicap (M), MiniChrom Column Fractogel® TMAE Hicap (M), volume 1 mL, prepacked column1250550001
Fractogel® EMD TMAE Hicap (M), MiniChrom Column Fractogel® TMAE Hicap (M), volume 5 mL, prepacked column1250700001
Cation ExchangeEshmuno® CPX Resin, MiniChrom Column Eshmuno® CPX, volume 1 mL, prepacked column1251560001
Eshmuno® CPX Resin, MiniChrom Column Eshmuno® CPX, volume 5 mL, prepacked column1251570001
Eshmuno® CPS Resin, MiniChrom Column Eshmuno® CPS, volume 1 mL, prepacked column1251640001
Eshmuno® CPS Resin, MiniChrom Column Eshmuno® CPS, volume 5 mL, prepacked column1251650001
MiniChrom Column Eshmuno® CP-FT, 0.2ml1251700001
Fractogel® EMD SO3 ⁻ (M) Resin, MiniChrom Column Fractogel® SO3 (M), volume 1 mL, prepacked column1250610001
Fractogel® EMD SO3 ⁻ (M) Resin, MiniChrom Column Fractogel® SO3 (M), volume 5 mL, prepacked column1250720001
Fractogel® EMD SE Hicap (M), MiniChrom Fractogel® SE Hicap (M), volume 1 mL, prepacked column1250600001
Fractogel® EMD SE Hicap (M), MiniChrom Fractogel® SE Hicap (M), volume 5 mL, prepacked column1250810001
Mixed Mode ChromatgraphyEshmuno® CMX Resin, MiniChrom Column Eshmuno® CMX, volume 1 mL, prepacked column1251850001
Eshmuno® CMX Resin, MiniChrom Column Eshmuno® CMX, volume 5 mL, prepacked column1251860001
Virus FiltrationViresolve® Pro Micro 40 Device KitVPMKVALNB9
Viresolve® Pro Micro Shield H KitVPMHKITNB9
Concentration/DiafiltrationPellicon® XL Cassette with Ultracel® Membrane, filtration area 50 cm2Custom R&D
Final FiltrationDurapore® 0.22 µm, OptiScale® Capsule, OptiScale® 25, filtration area 3.5 cm2SVGLA25NB6

Interested into our full capabilities for your Monoclonal Antibody process? Browse the Biopharmaceutical Application Guide  to help you find the right products and services for your needs.

 

Talk to One of our Experts Today

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Bioprocessing Cell Culture Media
Our off-the-shelf and customizable bioprocessing cell culture media (CCM) products enhance productivity in upstream mAb, vaccine, gene/cell therapy processes.
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The Mobius® Bioreactor family includes the bench scale (2 mL and 3 L), pilot, clinical and commercial manufacturing (50 – 2,000 L) single-use bioreactors that enable cell culturing capabilities from early process development through commercial batch production.
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Affinity chromatography is often used during the capture phase to isolate the target molecule and reduce process volume. Our range of affinity resins includes Protein A, anti-A and anti-B, and metal chelate resin, designed for high throughput and cost-effective purification.
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Optimize downstream purification using membrane chromatography for capture and polishing. Natrix membranes boost economics and facility efficiency.
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Ion exchange (IEX) chromatography separates biomolecules based on the difference in charge between the target molecule and chromatography resin.
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Partner with us for comprehensive cell and viral bank testing strategies, ensuring robust viral detection.
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Ensure mAb biotherapy safety, purity, and potency during development with product characterization services and assay packages from concept to clinic.
Analytical Development and Characterization for Adeno-Associated Virus (AAV)
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