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Key Documents

SML0978

Sigma-Aldrich

ML291

≥98% (HPLC)

Synonym(s):

CID52940465, N-(4-((4-Chloropiperidin-1-yl)sulfonyl)phenyl)-5-nitrofuran-2-carboxamide, SID134228465

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About This Item

Empirical Formula (Hill Notation):
C16H16ClN3O6S
CAS Number:
1523437-16-2
Molecular Weight:
413.83
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

ML291 specifically activates the apoptotic arm of the cellular unfolded protein response ( UPR) EC50 = 762 nM) with 105-fold selectivity over activation of the adaptive UPR pathway. ML291 induces apoptosis in wild-type mouse embryonic fibroblasts (MEFs), but not in CHOP KO MEFs.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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