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Aphidicolin from Nigrospora sphaerica

Name: Aphidicolin from <I>Nigrospora sphaerica</I>
Brand: SIGMA

≥98% (HPLC), DNA polymerase inhibitor, powder

Synonym(s):

APC

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₃₄O₄

CAS Number:

38966-21-1

Molecular Weight:

338.48

NACRES:

NA.77

PubChem Substance ID:

57653817

UNSPSC Code:

12352200

MDL number:

MFCD00083214

Beilstein/REAXYS Number:

4689958

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Aphidicolin from Nigrospora sphaerica, ≥98% (HPLC), powder

Quality Segment

300

assay

≥98% (HPLC)

form

powder

optical activity

[α]27/D +12°, c = 1 in methanol(lit.)

color

white

mp

227-233 °C (lit.)

solubility

ethanol: 1 mg/mL (stable at least a week at 4°C.), DMSO: 10 mg/mL (stable at least six weeks at −20°C.), methanol: 10 mg/mL, H₂O: insoluble

antibiotic activity spectrum

neoplastics, viruses

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

[H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

InChI key

NOFOAYPPHIUXJR-APNQCZIXSA-N

Gene Information

human ... POLA1(5422), POLD1(5424), POLG(5428)

Description

Biochem/physiol Actions

Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Disclaimer

Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.

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This Item	SML0075	SML0230	SML0229
Sigma-Aldrich A0781 Aphidicolin from Nigrospora sphaerica	Sigma-Aldrich SML0075 OBAA	Sigma-Aldrich SML0230 GW-803430	Sigma-Aldrich SML0229 CIQ
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 300	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility ethanol: 1 mg/mL (stable at least a week at 4°C.), methanol: 10 mg/mL, DMSO: 10 mg/mL (stable at least six weeks at −20°C.), H₂O: insoluble	solubility DMSO: ≥5 mg/mL at 60 °C	solubility DMSO: ≥4 mg/mL at warmed to 60 °C	solubility DMSO: ≥10 mg/mL at warmed to 60 °C
color white	color white to tan	color white to beige	color white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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