S4776
Somatotropin from human pituitary
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), lyophilized powder
Synonym(s):
Growth Hormone, STH
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About This Item
form:
lyophilized powder
Assay:
≥95% (SDS-PAGE)
Recommended Products
recombinant
expressed in E. coli
Quality Level
sterility
non-sterile
Assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
0.025-0.1 ng/mL cell proliferation using Nb2-11 cells per bioactivity ED50
mol wt
predicted mol wt ~22 kDa
drug control
Home Office Schedule 4.2
impurities
endotoxin, tested
solubility
PBS: 0.100 mL, clear, colorless (with 0.1% BSA )
shipped in
ambient
storage temp.
−20°C
General description
Somatotropin or growth hormone is a peptide hormone that is secreted by the anterior pituitary gland. It is essential for growth. The hormone increases muscle mass, reduces fat mass, helps in maintaining normal blood glucose levels and also promotes a balanced lipid profile.
Application
Somatotropin or growth hormone has been used to study the molecular interactions of ephrin type-A receptor 4 precursor (EphA4) with the growth hormone receptor. It has also been used to induce differentiation in mammary epithelial cell line HC11.
Biochem/physiol Actions
Increases mass of most tissues by increasing cell number rather than cell size, mobilizes fat stores.
Physical form
Lyophilized from a 0.2 μm filtered solution in TBS (20 mM Tris, 0.15 M NaCl, pH 8.5) containing 50 μg of BSA per 1 μg of cytokine.
Reconstitution
It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Quantitative analysis of the expression of whey acidic protein (WAP) mRNA in the prolactin-responsive mouse mammary gland epithelial cell line, HC11
Kawamata, Yuji, et al
Journal of Reproduction and Development (2001)
Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B
Takahiro Sawada
PLoS ONE (2017)
Yun Pang et al.
Kidney international, 90(6), 1357-1367 (2016-10-18)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by overproduction of numerous autoantibodies. Many studies have sought to identify such biomarkers to distinguish patients with active lupus nephritis from SLE patients without renal involvement. Because antibodies to complement C1q
Kin-Sing Wong et al.
Journal of chromatography. A, 1478, 35-42 (2016-12-05)
Growth hormone (GH), or somatotropin, is a protein that may enhance physical performance and facilitate growth and wound healing. For this reason, growth hormones and their recombinant analogues are prohibited in human sports by the World Anti-Doping Agency (WADA) and
Maximilian Bielohuby et al.
Disease models & mechanisms, 7(11), 1263-1273 (2014-09-23)
The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact
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