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UC448

Sigma-Aldrich

Paracetamol sulfate potassium salt

solid, ≥97% (HPLC)

Synonym(s):

4-Acetamidophenol sulfate ester potassium salt, Acetaminophen sulfate potassium salt, N-(4-Sulfoxyphenyl)acetamide monopotassium salt

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About This Item

Empirical Formula (Hill Notation):
C8H8KNO5S
CAS Number:
32113-41-0
Molecular Weight:
269.32
MDL number:
MFCD01631667
UNSPSC Code:
12161501
PubChem Substance ID:
329827671
NACRES:
NA.77

Assay

≥97% (HPLC)

form

solid

color

white to off-white

mp

163 °C

solubility

H2O: soluble

storage temp.

2-8°C

SMILES string

[K+].CC(=O)Nc1ccc(OS([O-])(=O)=O)cc1

InChI

1S/C8H9NO5S.K/c1-6(10)9-7-2-4-8(5-3-7)14-15(11,12)13;/h2-5H,1H3,(H,9,10)(H,11,12,13);/q;+1/p-1

InChI key

AJYPYWFCUWHZMZ-UHFFFAOYSA-M

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General description

Paracetamol is an aminophenol derivative. It functions as an analgesic and antipyretic drug, which has weak inflammatory effect. Paracetamol is used to treat pyrexia and mild to moderate pain. It might inhibit atherosclerosis through its antioxidant activity.

Application

Paracetamol sulfate potassium salt has been used as a standard for HPLC assays of acetaminophen.

Biochem/physiol Actions

Phase II metabolite of paracetamol.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Paracetamol sulfate potassium salt is soluble in water.

Other Notes

Occasionally, it may be necessary to supply as the sodium salt

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H315,H317,H318,H335

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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D Bougie et al.
Blood, 97(12), 3846-3850 (2001-06-05)
In patients suspected of having drug-induced immune thrombocytopenia, antibodies reactive with normal platelets in the presence of the suspect drug can sometimes be identified, but negative results are often obtained. One reason for this is that drug metabolites, formed in
Paracetamol: past, present, and future.
Prescott LF
American Journal of Therapeutics, 7(2), 143-147 (2000)
Hayati Filik et al.
Chemical & pharmaceutical bulletin, 54(6), 891-896 (2006-06-07)
In the present paper, conventional spectrophotometry in conjunction with cloud point extraction-preconcentration were investigated as alternative methods for paracetamol (PCT) assay in urine samples. Cloud point extraction (CPE) was employed for the preconcentration of p-aminophenol (PAP) prior to spectrophotometric determination
H Xiong et al.
The Journal of pharmacology and experimental therapeutics, 295(2), 512-518 (2000-10-25)
Previous studies have demonstrated that phenobarbital treatment impairs the biliary excretion of acetaminophen glucuronide (AG), although the transport system(s) responsible for AG excretion into bile has not been identified. Initial studies in rat canalicular liver plasma membrane vesicles indicated that
Caroline D van der Marel et al.
European journal of clinical pharmacology, 59(3), 243-251 (2003-05-23)
Data concerning metabolism of paracetamol in infants are scant. Previous studies have examined urinary metabolite recovery rates after a single dose of paracetamol in either neonates (<6 weeks) or children (3-9 years). There are no studies investigating infants. Infants (
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