SAB3500122

Monoclonal Anti-PD-1 antibody produced in mouse

clone 7A11B1, purified immunoglobulin, buffered aqueous solution

• Synonym(s): Anti-CD279, Anti-PDCD-1, Anti-Programmed cell death 1
• MDL number: MFCD02095740
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 7A11B1, monoclonal
• form: buffered aqueous solution
• species reactivity: mouse, human, rat
• technique(s): immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• UniProt accession no.: Q15116
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PDCD1(5133)

Description

General description

Programmed cell death 1 protein (PDCD1) is mapped to human chromosome 2q37.3. PDCD1 belongs to the Cluster of Differentiation 28 (CD28) family of receptors and has an immunoinhibitory domain. It is expressed in T and B lymphocytes.

Immunogen

raised against an ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.

Biochem/physiol Actions

Programmed cell death 1 protein (PDCD1) modulates lymphocyte activation. Single nucleotide polymorphisms in PDCD1 is implicated in systemic lupus erythematosus, an autoimmune inflammatory disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable