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C6645
Cytosine β-D-arabinofuranoside hydrochloride
crystalline
Synonym(s):
1-(β-D-Arabinofuranosyl)cytosine hydrochloride, Ara-C hydrochloride, Arabinocytidine hydrochloride, Arabinosylcytosine hydrochloride, Cytarabine hydrochloride, Cytosine arabinoside hydrochloride
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25 MG
$85.10
100 MG
$114.00
500 MG
$337.00
1 G
$552.00
5 G
$2,250.00
$85.10
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25 MG
$85.10
100 MG
$114.00
500 MG
$337.00
1 G
$552.00
5 G
$2,250.00
About This Item
Empirical Formula (Hill Notation):
C9H13N3O5 · HCl
CAS Number:
Molecular Weight:
279.68
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
$85.10
In StockDetails
Recommended Products
biological source
synthetic (inorganic)
Quality Level
Assay
≥99% (HPLC)
form
crystalline
mp
197-198 °C (lit.)
storage temp.
2-8°C
SMILES string
Cl[H].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
InChI
1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1
InChI key
KCURWTAZOZXKSJ-JBMRGDGGSA-N
Gene Information
human ... POLA1(5422) , POLA2(23649) , POLD1(5424) , POLD2(5425) , POLD3(10714) , POLD4(57804) , POLE(5426) , POLE2(5427) , POLE3(54107) , PRIM1(5557) , PRIM2(5558)
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Application
Cytosine β-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco′s modified eagle medium (FBS-DMEM)[1] and B27/neurobasal-A medium[2] to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.[3]
Biochem/physiol Actions
Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Articles
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
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Hi I need the insert of this product please. Can you send me please? the batch number is SLCD2059
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