The Aurora Kinase Inhibitor II, also referenced under CAS 331770-21-9, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Aurora Kinase Inhibitor II, 4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline, Aurora Kinase Inhibitor II
A cell-permeable anilinoquinazoline compound that acts as a potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC50 = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.
A cell-permeable, potent, selective, and ATP-competitive inhibitor of Aurora kinases (IC50 = 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells). Due to its limited aqueous solubility and high serum binding property, it is recommended for in vitro, but not in vivo, use.
Biochem/physiol Actions
Cell permeable: yes
Primary Target Aurora Kinase
Product competes with ATP.
Reversible: no
Target IC50: 310 nM and 240 nM for Aurora A and B, respectively, 1.25 µM in MCF7 cells
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Other Notes
Heron, N.M., et al. 2006. Bioorg. Med. Chem. Lett.16, 1320. Mortlock, A.A., et al. 2005. Curr. Top. Med. Chem.5, 807.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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