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790528P

Avanti

18:1 DGS-NTA

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt), powder

Synonym(s):

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt); DOGS NTA

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About This Item

Empirical Formula (Hill Notation):
C53H100N5O13
CAS Number:
474942-78-4
Molecular Weight:
1015.39
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 5 mg (790528P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 790528P

shipped in

dry ice

storage temp.

−20°C

General description

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (18:1 DGS-NTA) is amphiphile. DGS-NTA is a nitrilotriacetic acid -functionalized amphiphile devoid of nickel ion.

Application

18:1 DGS-NTA 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (ammonium salt) has been used:
  • for generation of amphiphile monolayer
  • in NTA-liposome preparation for procoagulant binding studies and to study its effect on factor FXII autoactivation
  • as a liposome component for lipid bilayer preparation for surface plasmon resonance studies

Biochem/physiol Actions

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (18:1 DGS-NTA or DOGS-NTA) cannot bind to histidine due to lack of nickel ion. It is capable of self-assembly to form a stable monolayer. DOGS-NTA ammonium salt is useful in bicelle preparation.

Packaging

5 mL Clear Glass Sealed Ampule (790528P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N J Mutch et al.
Journal of thrombosis and haemostasis : JTH, 10(10), 2108-2115 (2012-08-22)
Upon contact with an appropriate surface, factor XII (FXII) undergoes autoactivation or cleavage by kallikrein. Zn(2+) is known to facilitate binding of FXII and the cofactor, high molecular weight kininogen (HK), to anionic surfaces. To investigate whether transition metal ions
Ronald D Seidel et al.
Journal of the American Chemical Society, 129(15), 4834-4839 (2007-03-28)
The study of bound-state conformations of ligands interacting with proteins is important to the understanding of protein function and the design of drugs that alter function. Traditionally, transferred nuclear Overhauser effects (trNOEs), measured from NMR spectra of ligands in rapid
E Barklis et al.
The EMBO journal, 16(6), 1199-1213 (1997-03-17)
We have developed a system for analysis of histidine-tagged (His-tagged) retrovirus core (Gag) proteins, assembled in vitro on lipid monolayers consisting of egg phosphatidylcholine (PC) plus the novel lipid DHGN. DHGN was shown to chelate nickel by atomic absorption spectrometry
C Vénien-Bryan et al.
Journal of molecular biology, 274(5), 687-692 (1998-02-07)
Two-dimensional crystals of the histidine-tagged-HupR protein, a transcriptional regulator from the photosynthetic bacterium Rhodobacter capsulatus, were obtained upon specific interaction with a Ni2+-chelated lipid monolayer. HupR is a response regulator of the NtrC family; it activates the transcription of the
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