205206
2-Amino-5-bromo-6-methyl-4-pyrimidinol
97%
Synonym(s):
5-Bromo-6-methylisocytosine
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About This Item
Empirical Formula (Hill Notation):
C5H6BrN3O
CAS Number:
Molecular Weight:
204.02
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
97%
mp
244-246 °C (lit.)
functional group
bromo
SMILES string
Cc1nc(N)nc(O)c1Br
InChI
1S/C5H6BrN3O/c1-2-3(6)4(10)9-5(7)8-2/h1H3,(H3,7,8,9,10)
InChI key
ADLWOFHKMXUDKF-UHFFFAOYSA-N
General description
2-Amino-5-bromo-6-methyl-4-pyrimidinol induced high levels of serum interferon in mice[1].
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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P S Morahan et al.
Antiviral research, 15(3), 241-254 (1991-03-01)
The question of whether interferon alpha/beta is the common mechanism of antiviral action of synthetic immunomodulators was investigated in B6C3F1 mice infected with Semliki Forest virus. Mice were treated with various concentrations of normal sheep serum or potent anti-alpha/beta interferon
L S Anthony et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 7(4), 343-348 (1984-01-01)
The modulation of murine host resistance to infection with Listeria monocytogenes by the substituted pyrimidine anti-viral compounds, 2-amino-5-bromo-6-methyl-4-pyrimidinol (ABMP), 2-amino-5-bromo-6-phenyl-4-pyrimidinol (ABPP) and 2-amino-5-iodo-6-phenyl-4-pyrimidinol (AIPP) was investigated. BAF1 mice given three daily injections of ABMP, ABPP (as well as of the
Antineoplastic properties of pyrimidinone interferon inducers.
D A Stringfellow
Advances in enzyme regulation, 19, 335-348 (1980-01-01)
D A Stringfellow et al.
Journal of interferon research, 1(1), 1-14 (1980-01-01)
The interferon inducing characteristics of a new series of 6-phenyl pyrimidinol compounds are described and compared against a previously identified pyrimidine, 2-amino-5-bromo-6-methyl-4-pyrimidinol (ABMP). Interestingly, a split in ability to induce interferon but not in vivo antiviral activity was observed in
D A Stringfellow
Antimicrobial agents and chemotherapy, 17(3), 455-460 (1980-03-01)
Prostaglandins enhanced the interferon response and therapeutic activity of interferon inducers in Friend leukemia virus-infected mice. A similar enhancement in interfron responsiveness but not antiviral activity was observed in mice infected with rapidly acute viruses.
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