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178950

Sigma-Aldrich

Methanesulfonyl fluoride

98%

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About This Item

Linear Formula:
CH3SO2F
CAS Number:
Molecular Weight:
98.10
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

Assay

98%

reaction suitability

reaction type: click chemistry

bp

123-124 °C (lit.)

density

1.427 g/mL at 25 °C (lit.)

SMILES string

CS(F)(=O)=O

InChI

1S/CH3FO2S/c1-5(2,3)4/h1H3

InChI key

KNWQLFOXPQZGPX-UHFFFAOYSA-N

General description

Methanesulfonyl fluoride is an anticholinesterase (antiChEs), used to treat Alzheimer′s disease. It is a thrombin inhibitor.

Pictograms

Skull and crossbonesCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Biochemical pharmacology, 35(14), 2287-2296 (1986-07-15)
The binding of D-tubocurarine (TC) to acetylcholinesterase (AChE) was studied using different methods of enzyme kinetics. The main results are as follows. TC reversibly inhibits the hydrolysis of different substrates of AChE with three different inhibition constants (Ki1 = 7.0
D H Malin et al.
Neurobiology of aging, 12(2), 181-183 (1991-03-01)
In previous studies, 18-month-old rats have shown no significant retention 24 hours after the single acquisition trial in a one-trial discriminative reward learning task. In the present study, ten 18-month-old rats pretreated with 0.5 mg/kg MSF IP showed significantly better
P Masson et al.
Biochimica et biophysica acta, 869(3), 304-313 (1986-02-14)
In order to determine whether a structural modification at the active center of cholinesterase may alter the conformational stability of the enzyme we compared the urea-induced unfolding of the tetrameric form of non-inhibited and irreversibly inhibited human plasma cholinesterase (acylcholine
D H Malin et al.
Neurobiology of aging, 14(4), 393-395 (1993-07-01)
Aged (24-month-old) rats were treated chronically with methanesulfonyl fluoride (MSF), an acetylcholinesterase (AChE) inhibitor with selectivity for central nervous system AChE, or with injection vehicle alone. Twelve 0.22 mg/kg IP injections were given over 4 weeks. MSF rats showed significantly

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