SML3933
CLC-2 channel inhibitor, AK-42
≥98% (HPLC)
Synonym(s):
2-[[2,6-Dichloro-3-(phenylmethoxy)phenyl]amino]-3-pyridinecarboxylic acid, AK-42
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About This Item
Empirical Formula (Hill Notation):
C19H14Cl2N2O3
CAS Number:
Molecular Weight:
389.23
UNSPSC Code:
12352200
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
O=C(C1=C(NC2=C(Cl)C=CC(OCC3=CC=CC=C3)=C2Cl)N=CC=C1)O
Biochem/physiol Actions
Specific and potent CLC-2 chloride channel inhibitor that binds to the CLC-2 channel extracellularly.
CLC-2 channel inhibitor AK-42 is a specific and potent CLC-2 chloride channel inhibitor that binds to the CLC-2 channel extracellularly. AK-42 causes selective and reversible blocking of CLC-2 currents.
CLC-2 channel inhibitor AK-42 is a specific and potent CLC-2 chloride channel inhibitor that binds to the CLC-2 channel extracellularly. AK-42 causes selective and reversible blocking of CLC-2 currents.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Anna K Koster et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(51), 32711-32721 (2020-12-06)
CLC-2 is a voltage-gated chloride channel that is widely expressed in mammalian tissues. In the central nervous system, CLC-2 appears in neurons and glia. Studies to define how this channel contributes to normal and pathophysiological function in the central nervous
Apurva A Oak et al.
Molecular pharmacology, 102(2), 106-115 (2022-06-10)
Loss of prosecretory Cl- channel CFTR activity is considered as the key cause of gastrointestinal disorders in cystic fibrosis including constipation and meconium ileus. Clc-2 is proposed as an alternative Cl- channel in intestinal epithelia that can compensate for CFTR
Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nature Communications, 14(1), 3424-3424 (2023)
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