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Key Documents

SML0915

Sigma-Aldrich

Xipamide

≥98% (HPLC)

Synonym(s):

5-(Aminosulfonyl)-4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-benzamide, BE 1293, BEI 1293, MJF 10938

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10 MG
€55.80
50 MG
€204.00

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Estimated to ship on27 April 2025

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10 MG
€55.80
50 MG
€204.00

About This Item

Empirical Formula (Hill Notation):
C15H15ClN2O4S
CAS Number:
14293-44-8
Molecular Weight:
354.81
EC Number:
238-216-4
UNSPSC Code:
12352200
NACRES:
NA.77

€55.80

Estimated to ship on27 April 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

[S](=O)(=O)(N)c1c(cc(c(c1)C(=O)Nc2c(cccc2C)C)O)Cl

InChI

1S/C15H15ClN2O4S/c1-8-4-3-5-9(2)14(8)18-15(20)10-6-13(23(17,21)22)11(16)7-12(10)19/h3-7,19H,1-2H3,(H,18,20)(H2,17,21,22)

InChI key

MTZBBNMLMNBNJL-UHFFFAOYSA-N

Biochem/physiol Actions

Xipamide is a sulfonamide diuretic that blocks sodium reabsorption in the distal tubules of the kidney, resulting in increased urine output. Xiopamide also blocks the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.
Xipamide is a sulfonamide diuretic.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000403972
0000305465
0000403972
0000236326
014M4718V

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Anton Sandhofer et al.
Wiener klinische Wochenschrift, 114(21-22), 938-942 (2003-01-17)
Diuretics are among the most frequently prescribed substances in elderly patients, but they are also associated with the highest incidence of adverse effects in this group of patients. Xipamide is a sulfonamide-like diuretic whose action does not depend on transtubular
U Akesolo et al.
Journal of chromatographic science, 42(2), 74-79 (2004-03-17)
Experimental design methodologies are applied to the development of a capillary zone electrophoretic method for the separation of the angiotensin-converting enzyme inhibitor enalapril and its derivative enalaprilat and the diuretics xipamide and hydrochlorothiazide. The effects of pH, buffer concentration, proportion
Xipamide induced symptomatic severe hyponatraemia.
S C Mishra et al.
The Journal of the Association of Physicians of India, 39(2), 229-230 (1991-02-01)
S Youssef et al.
International journal of clinical pharmacology research, 12(3), 109-116 (1992-01-01)
Serum lipids of 80 patients with moderately severe essential hypertension under four different antihypertensive therapies were compared to ten matched hypertensives on a placebo, after eight weeks of therapy. The results in the serum lipid parameters measured after therapy showed
F Soria et al.
Revista espanola de cardiologia, 44(6), 389-394 (1991-06-01)
With the objective of trying to prove the regression of ventricular mass in patients with essential hypertension, with and without left ventricular hypertrophy (LVH), we studied 42 patients of both sexes with echocardiography, measuring the left ventricular mass (LVM), the
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