I0786
IGF1R (960-end), active, His tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
CD221, JTK13, MGC142170, MGC142172
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About This Item
UNSPSC Code:
51111800
NACRES:
NA.32
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
224-302 nmol/min·mg
mol wt
~53 kDa
UniProt accession no.
relevant disease(s)
cancer
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IGF1R(3480)
Biochem/physiol Actions
IGF1R (insulin-like growth factor 1 receptor) is a transmembrane tyrosine kinase receptor that is activated by IGF1 (insulin-like growth factor 1) as well as IGF2. IGF1R plays a key role in tumorigenesis. The IGF1R is implicated in several cancers, most notably breast cancer where it is highly overexpressed and causes disease progression and poor prognosis. In many instances, IGF1R overexpression allows cancerous cells to resist the cytotoxic properties of chemotheraputic drugs or radiotherapy.
Physical form
Supplied in 50 mM Sodium Phosphate, pH 7.0, with 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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H E Jones et al.
Endocrine-related cancer, 11(4), 793-814 (2004-12-23)
De novo and acquired resistance to the anti-tumour drug gefitinib (ZD1839; Iressa), a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) has been reported. We have determined whether signalling through the IGF-I receptor (IGF-1R) pathway plays a role
Tracking changes in hypothalamic IGF-1 sensitivity with aging and caloric restriction.
Yaghmaie, F., et al.
Experimental Gerontology, 42, 148-149 (2007)
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