Poly(Glu,Tyr) (poly(Glu,Tyr) 4:1 random copolymer) is used as a substrate for the evaluation of protein tyrosine kinase(s).
Poly(Glu,Tyr) 4:1 is a polyamino acid used in the manufacture of electrochemical biosensors for detection of reactions such as Fenton induced tyrosine oxidation.
Journal of agricultural and food chemistry, 56(18), 8692-8698 (2008-09-02)
Oxidation of 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) by lactoperoxidase was found to be inhibited by tyrosine-containing random amino acid copolymers but not by tyrosine. Both electrostatic effects and polymer size were found to be important by comparison of negatively and positively charged copolymers
In this report, we determined protein tyrosine kinase (PTKs) activity in human epidermoid carcinoma cells (A431) by employing a novel electrochemical method using boron-doped diamond (BDD) electrodes that enables the electrochemical oxidation of tyrosine (Tyr), phosphorylated Tyr (Tyr-P) and sulfated
The cellular mechanisms for the insulin resistance of pregnancy and gestational diabetes mellitus (GDM) are unknown. The membrane protein plasma cell membrane glycoprotein-1 (PC-1) has been identified as an inhibitor of insulin receptor tyrosine kinase (IRTK) activity. We investigated insulin
A simple and sensitive electrochemical biosensor was used to detect tyrosine oxidation induced by hydroxyl radicals generated by Fenton reaction (Fe(2+)/H(2)O(2)). Poly(glu, tyr) (4:1) peptides were immobilized on indium tin oxide (ITO) electrode surface via layer-by-layer assembly technique, and Os(bpy)(3)(2+)-mediated
Journal of receptor and signal transduction research, 25(1), 45-56 (2005-06-18)
Receptor tyrosine kinases (PTKs) play key roles in the pathogenesis of numerous human diseases, including cancer, and therefore PTK inhibitors are currently under intense investigation as potential drug candidates. PTK inhibitor screening data are, however, poorly comparable because of the
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.
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