939005
Cesium Fluoride ChemBeads
NSC 84270
Synonym(s):
CsF
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About This Item
Empirical Formula (Hill Notation):
CsF
CAS Number:
Molecular Weight:
151.90
MDL number:
UNSPSC Code:
12352100
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Quality Level
form
solid
composition
, 14-16 wt. % (loading of base)
SMILES string
[F-].[Cs+]
InChI
1S/Cs.FH/h;1H/q+1;/p-1
InChI key
XJHCXCQVJFPJIK-UHFFFAOYSA-M
General description
Cesium fluoride is an inorganic compound known to be a source of fluoride ion and a catalyst in organic synthesis. It has been used in many organic reactions like 1,4−elimination, desilylation, transesterification, acylation, nucleophilic aromatic substitution, etherification, cross−coupling reactions and so on.
Application
Cesium fluoride can be used as:
A base in the Suzuki cross-coupling synthesis of ortho-substituted biaryls.
A reagent for the nucleophilic fluorination of primary halides and sulfonates in protic media such as tert-butyl and tert-pentyl alcohols.
Reactant for:
Preparation of building blocks for synthesis of fluoroallylic compounds
Synthesis of alcohols via hydrolysis of alkyl silyl ethers at neutral pH in buffered mixed organic-aqueous solutions
Nucleophilic fluorination of alkynyliodonium salts to form fluorovinylic compounds
Nucleophilic aromatic substitution (SNAr) reactions
Used in the successful synthesis of a single-crystal Dion-Jacobson phase, CsLaTa2O7, that has applications in photocatalysis and superconductivity.
For general uses, product is also available in powdered form (198323)
A base in the Suzuki cross-coupling synthesis of ortho-substituted biaryls.
A reagent for the nucleophilic fluorination of primary halides and sulfonates in protic media such as tert-butyl and tert-pentyl alcohols.
Reactant for:
Preparation of building blocks for synthesis of fluoroallylic compounds
Synthesis of alcohols via hydrolysis of alkyl silyl ethers at neutral pH in buffered mixed organic-aqueous solutions
Nucleophilic fluorination of alkynyliodonium salts to form fluorovinylic compounds
Nucleophilic aromatic substitution (SNAr) reactions
Used in the successful synthesis of a single-crystal Dion-Jacobson phase, CsLaTa2O7, that has applications in photocatalysis and superconductivity.
For general uses, product is also available in powdered form (198323)
Features and Benefits
ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.
Other Notes
High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads
Versatile Methods to Dispense Sub-Milligram Quantities of Solids using Chemical Coated Beads for High-Throughput Experimentation
ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand
Versatile Methods to Dispense Sub-Milligram Quantities of Solids using Chemical Coated Beads for High-Throughput Experimentation
ChemBead Enabled High-Throughput Cross-Electrophile Coupling Reveals a New Complementary Ligand
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Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Repr. 2 - STOT RE 2
Target Organs
Kidney,Adrenal gland
Supplementary Hazards
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Dong Wook Kim et al.
Journal of the American Chemical Society, 128(50), 16394-16397 (2006-12-15)
Aprotic solvents are usually preferred for the SN2 reactions, because nucleophilicity and hence SN2 reactivity are severely retarded by the influence of the partial positive charge of protic solvents. In this work, we introduce a remarkable effect of using tertiary
Shengcai Zheng et al.
Chemical communications (Cambridge, England), 47(24), 6969-6971 (2011-05-20)
One pot asymmetrical double allylations of sodium sulfide catalyzed by an iridium complex along with a combination of caesium fluoride and water in dichloromethane have been realized and the double allylation products with two C-S bond chiral centers were obtained
Timothy Noël et al.
Angewandte Chemie (International ed. in English), 50(38), 8900-8903 (2011-08-13)
[Image: see text] A flow process for Pd-catalyzed carbon fluorine bond formation is described. A microreactor using a packed-bed design allows for easy handling of large quantities of insoluble CsF with precise control over reaction times, efficient mixing, and the
Michael C Willis et al.
Chemical communications (Cambridge, England), (8)(8), 832-833 (2002-07-19)
Treatment of a benzyl substituted meso-ditriflate with boronic acids in the presence of palladium acetate, triphenylphosphine and caesium fluoride results in intermolecular Suzuki coupling followed by vinyl triflate-arene cyclisation to provide, in high yields, single regioisomers of tricyclic-carbocycles.
Takashi Okitsu et al.
Chemical communications (Cambridge, England), (47)(47), 6330-6332 (2008-12-03)
A highly efficient and rapid total synthesis of 9Z-retinoic acid was accomplished by caesium fluoride-promoted Stille coupling reaction; using a common building block, 9Z-retinoic acid analogues were also prepared by the same method without isomerisation of the Z-double bond.
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