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901422

Sigma-Aldrich

Poly(N-isopropylacrylamide)

average Mn 85,000

Synonym(s):

NIPAM polymer, PNIPAM, PolyNIPAM, Polyacrylamide, polyNIPAM

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About This Item

Linear Formula:
CH3(C6H11NO)nCH3
CAS Number:
25189-55-3
MDL number:
MFCD00284282
UNSPSC Code:
12162002
NACRES:
NA.23

form

crystals

mol wt

Mn 60,000-110,000 Da by MALLS (GPC)
average Mn 85,000

color

white to off-white

mp

96 °C

storage temp.

2-8°C

SMILES string

CC(C)NC(=O)C=C

InChI

1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)

InChI key

WDFKEEALECCKTJ-UHFFFAOYSA-N

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General description

Poly(N-isopropylacrylamide) (PNIPAM) is a temperature-responsive polymer used in biomedical research applications. PNIPAM undergoes a reversible, lower critical solution temperature (LCST) phase transition when heated above 32 °C, transitioning from a soluble to an insoluble material. PNIPAM is also frequently crosslinked to yield hydrogels with reversible, thermal shrinking and swelling. Poly(N-isopropylacrylamide) is also readily functionalized and has been used as the hydrophilic block in the synthesis of thermoresponsive, amphiphilic block copolymers. Due to the similarity in temperature between the LCST of PNIPAM and the temperature of the human body, PNIPAM materials have been frequently utilized in tissue engineering and controlled drug delivery research applications.

Application

PNIPAM can be used in the formation of a smart hydrogel, which finds potential usage in sensors, fuel cells, supercapacitors, and lithium-ion batteries.[1] It can also be used in the fabrication of molecular nanothermometer.[2] PNIPAM is coated with gold nanoparticles (AuNPs) to form microgels that facilitate highly reproducible signals for surface-enhanced Raman scattering (SERS).[3]
Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCJ4783

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Muhammad Abdul Haq et al.
Materials science & engineering. C, Materials for biological applications, 70(Pt 1), 842-855 (2016-10-25)
Materials which adjust their properties in response to environmental factors such as temperature, pH and ionic strength are rapidly evolving and known as smart materials. Hydrogels formed by smart polymers have various applications. Among the smart polymers, thermoresponsive polymer poly(N-isopropylacrylamide)(PNIPAM)
Nanorod-coated PNIPAM microgels: thermoresponsive optical properties
Karg M, et al.
Small, 3(7), 1222-1229 (2007)
Au@ pNIPAM colloids as molecular traps for surface-enhanced, spectroscopic, ultra-sensitive analysis
Alvarez-Puebla RA, et al.
Angewandte Chemie (International ed. in English), 48(1), 138-143 (2009)
Poly (N-isopropylacrylamide)(PNIPAM) is never hydrophobic
Pelton R, et al.
Journal of Colloid and Interface Science, 348(2), 673-674 (2010)
S Panja et al.
ACS applied materials & interfaces, 8(19), 12063-12074 (2016-04-30)
The design of nanomedicines from the tuned architecture polymer is a leading object of immense research in recent years. Here, smart thermoresponsive micelles were prepared from novel architecture four-arm star block copolymers, namely, pentaerythritol polycaprolactone-b-poly(N-isopropylacrylamide) and pentaerythritol polycaprolactone-b-poly(N-vinylcaprolactam). The polymers
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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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