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640611

Sigma-Aldrich

3-Chloro-7-hydroxy-4-methylcoumarin

97%

Synonym(s):

3-Chloro-4-methylumbelliferone

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About This Item

Empirical Formula (Hill Notation):
C10H7ClO3
CAS Number:
6174-86-3
Molecular Weight:
210.61
EC Number:
228-217-8
MDL number:
MFCD00006851
UNSPSC Code:
12352100
PubChem Substance ID:
24882654
NACRES:
NA.22

Assay

97%

form

solid

mp

240-244 °C (lit.)

SMILES string

CC1=C(Cl)C(=O)Oc2cc(O)ccc12

InChI

1S/C10H7ClO3/c1-5-7-3-2-6(12)4-8(7)14-10(13)9(5)11/h2-4,12H,1H3

InChI key

ODZHLDRQCZXQFQ-UHFFFAOYSA-N

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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J K Malik et al.
Archives of toxicology, 48(1), 51-59 (1981-08-01)
The biotransformation and disposition of 3-chloro-4-methyl-(4-14C)-7-hydroxycoumarin [(14C) chlorferron] were investigated in rats after single oral administration. Following administration of (14C) chlorferron at 0.5 and 20 mg/kg body weight to male rats, greater than 90% of the given dose was eliminated
Jiyeon Ha et al.
Bioresource technology, 98(10), 1916-1923 (2006-09-22)
Chlorferon and diethylthiophosphate (DETP) are the hydrolysis products of coumaphos, an organophosphate pesticide. In this research, two consortia of bacterial cultures, one responsible for degrading chlorferon and the other for degrading DETP, were selectively enriched from waste cattle dip solution.
J K Malik et al.
Advances in experimental medicine and biology, 136 Pt A, 839-846 (1981-01-01)
The distribution, excretion and biotransformation of 3-chloro-4-methyl-(4-14C)-7-hydroxycoumarin [(14C) chlorferron] were studied in the rats after single oral administration. Male and female Wistar rats were given single oral doses of 0.5 and 20.0 mg/kg body weight of (14C) chlorferron and routes
V Simeon-Rudolf et al.
Chemico-biological interactions, 119-120, 119-128 (1999-07-27)
Inhibition of recombinant mouse wild type AChE (EC 3.1.1.7) and BChE (EC 3.1.1.8), and AChE peripheral site-directed mutants and human serum BChE variants by 4,4'-bipyridine (4,4'-BP) and the coumarin derivative 3-chloro-7-hydroxy-4-methylcoumarin (CHMC) was studied. The enzyme activity was measured with
J K Malik et al.
Toxicology letters, 7(6), 449-452 (1981-03-01)
Administration of [14C]chlorferron in a single oral dose of 0.5 and 20 mg/kg body weight to female rats resulted in a urinary excretion of greater than 74% of the given dose during the first 24 h. Approx. 8% of the
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