Product 430471 has a dodecyl (12 carbon) ester on one end of the polymer chain and a hydroxyl end group on the other.
430471
Poly(D,L-lactide-co-glycolide)
ester terminated, Mw 50,000-75,000
Synonym(s):
Lactel® B6006-1, PLGA
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1 G
€69.00
5 G
€239.00
About This Item
Linear Formula:
[C3H4O2]x[C2H2O2]y
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
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Quality Level
form
amorphous
feed ratio
lactide:glycolide 85:15
mol wt
Mw 50,000-75,000
degradation timeframe
<6 months
viscosity
0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)
transition temp
Tg 45-50 °C
solubility
ethyl acetate, chloroform, acetone and THF: soluble
storage temp.
2-8°C
SMILES string
OCC(O)=O.CC(O)C(O)=O
InChI
1S/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)
InChI key
XBBVURRQGJPTHH-UHFFFAOYSA-N
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General description
Characteristic properties of ester terminated poly(D,L-lactide-co-glycolide) (PLGA) are in vivo biodegradability, tunable drug release profile and very high encapsulation capacity.[1]
Application
PLGA polymers find uses in the production of biodegradable medical sutures and for controlled drug release. PLGA microspheres have been reported for use in controlled release of human growth hormone.[1] Thin membranes of blended polymers constituting of PLGA/polycaprolactone/β-tricalcium phosphate have been used in guided bone regeneration.[2]
Features and Benefits
Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.
Physical form
Biocompatible, biodegradable polymer.
Legal Information
Lactel is a registered trademark of Evonik Corp
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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What are the end groups of Product No. 430471 (Poly(DL-lactide-co-glycolide)?
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What is the tensile strength of Product No. 403471 Poly(DL-lactide-co-glycolide)?
1 answer-
Product 430471 has a tensile strength of 6000 - 8000 psi, with an elongation of 3-10%.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the density of Product No. 430471 Poly(DL-lactide-co-glycolide)?
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According to the manufacturer, product 430471 has a theoretical density of 1.27g/mL.
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Is Product No. 403471 a resorbable polymer?
1 answer-
Yes, Product No. 430471 has a resorption time of 5-6 months.
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How is this Product No. 430471 synthesized (Poly(DL-lactide-co-glycolide)?
1 answer-
To synthesize product 430471, 1-dodecanol is used as an initiator and stannous octoate is used as a catalyst to start the ring opening polymerization of D,L-lactide and glycolide monomers.
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