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143634

Sigma-Aldrich

p-Tolyl isocyanate

99%

Synonym(s):

4-Methylphenyl isocyanate

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About This Item

Linear Formula:
CH3C6H4NCO
CAS Number:
622-58-2
Molecular Weight:
133.15
Beilstein:
471494
EC Number:
210-743-4
MDL number:
MFCD00002029
UNSPSC Code:
12352100
PubChem Substance ID:
24848599
NACRES:
NA.22

Assay

99%

form

liquid

refractive index

n20/D 1.531 (lit.)

bp

70-72 °C/10 mmHg (lit.)

density

1.056 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

Cc1ccc(cc1)N=C=O

InChI

1S/C8H7NO/c1-7-2-4-8(5-3-7)9-6-10/h2-5H,1H3

InChI key

MGYGFNQQGAQEON-UHFFFAOYSA-N

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General description

p-Tolyl isocyanate reacts with human serum albumin to form antigen which helps in detecting IgE antibodies in workers hypersensitive to toluene diisocyanate.

Application

p-Tolyl isocyanate was used to study the catalytic role of supported Rhodium(I) complex toward the reductive carbonylation of nitrobenzene in DMF medium.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1C - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

150.8 °F - closed cup

Flash Point(C)

66 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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J M Danks et al.
Clinical allergy, 11(2), 161-168 (1981-03-01)
Radioallergosorbent testing was used to look for the presence of specific IgE antibody against a para-tolyl-mono-isocyanate human serum albumin conjugate in sera from five groups of subjects. The first three groups consisted of individuals exposed to toluene diisocyanate (TDI) who
B T Butcher et al.
The Journal of allergy and clinical immunology, 70(4), 231-235 (1982-10-01)
Toluene diisocyanate (TDI) sensitivity accompanied by nonspecific bronchial hyperresponsiveness occurs in approximately 5% of occupationally exposed workers. We report the case of a 32-yr-old worker followed longitudinally after removal from isocyanate exposure. TDI reactivity was lost 11 mo after removal
Immunologic sensitization and pulmonary hypersensitivity by repeated inhalation of aromatic isocyanates.
M H Karol et al.
Toxicology and applied pharmacology, 53(2), 260-270 (1980-04-01)
[Technology of producing p-toluene isocyanate (C6H4CH3NCO) and a human albumin complex for clinical purposes].
E Sieradzki et al.
Acta poloniae pharmaceutica, 44(2), 237-241 (1987-01-01)
C J Game
American Industrial Hygiene Association journal, 43(10), 759-763 (1982-10-01)
Sera of 91 people were assayed for IgE which bound to a p-tolyl-isocyanate-human serum albumin conjugate. The sera came from 20 blood donors, 70 factory workers, and 1 casualty patient. Three factory workers had abnormally high assay values in association
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