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  • Structures and biomimetic synthesis of novel α-pyrone polyketides of an endophytic Penicillium sp. in Catharanthus roseus.

Structures and biomimetic synthesis of novel α-pyrone polyketides of an endophytic Penicillium sp. in Catharanthus roseus.

Organic letters (2013-02-15)
Teigo Asai, Dan Luo, Kouwa Yamashita, Yoshiteru Oshima
ZUSAMMENFASSUNG

Novel polyketides, citreoviripyrone A (1) and B (2), known citreomontanin (3), and (-)-citreoviridin (4) were isolated from the mycelium of the endophytic fungus. The endophytic fungus, which belongs to the genus Penicillium, was separated from surface-sterilized healthy leaves of Catharanthus roseus. The structures of 1 and 2 were determined on the basis of NMR data, and 1 was characterized as an α-pyrone polyketide featuring bicyclo[4.2.0]octadiene. The biomimetic synthesis of 1 and 2 from 3 elucidated a plausible biosynthetic pathway. Both Zn(II)-type and NAD(+)-dependent histone deacetylase inhibitors significantly enhanced the production of 1 and 3.

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2-Mercapto-ethansulfonsäure Natriumsalz, BioXtra, ≥98.0% (RT)
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2-Mercapto-ethansulfonsäure Natriumsalz, analytical standard, ≥98.0% (titration)
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2-Mercapto-ethansulfonsäure -Lösung, for protein sequence analysis, ampule, 3.0 M±0.1 M in H2O (T)
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