1356971

Letrozol

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 4,4′-(1H-1,2,4-Triazol-1-ylmethylen)-bisbenzonitril
• Empirische Formel (Hill-System): C₁₇H₁₁N₅
• CAS-Nummer: 112809-51-5
• Molekulargewicht: 285.30
• NACRES: NA.24
• PubChem Substance ID: 329750236
• UNSPSC Code: 41116107
• MDL number: MFCD00866241

Eigenschaften

• grade: pharmaceutical primary standard
• API family: letrozole
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
• InChI: 1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
• InChI key: HPJKCIUCZWXJDR-UHFFFAOYSA-N
• Gene Information: human ... CYP19A1(1588)

Beschreibung

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Letrozole USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Letrozole Tablets

Biochem/physiol Actions

Letrozol ist ein nicht-steroidaler Aromatase-Inhibitor der dritten Generation. Es ist ein kompetitiver Inhibitor des Aromatase Enzymsystems und verhindert so die Umwandlung von Androgenen zu Östrogenen. Letrozol hemmt Aromatase durch kompetitive Bindung an das Häm der Cytochrom-P450-Untereinheit des Enzyms, was zu einer Abnahme der Östrogen-Biosynthese in allen Geweben führt.

Letrozol ist ein nicht-steroidaler Aromatase-Inhibitor.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd,H373
• pcodes: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2 - STOT RE 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable