1091108

Capsaicin

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): trans-8-Methyl-N-vanillyl-6-nonensäureamid
• Lineare Formel: (CH₃)₂CHCH=CH(CH₂)₄CONHCH₂C₆H₃-4-(OH)-3-(OCH₃)
• CAS-Nummer: 404-86-4
• Molekulargewicht: 305.41
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329749225
• MDL number: MFCD00017259
• Beilstein/REAXYS Number: 2816484

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• API family: capsaicin
• manufacturer/tradename: USP
• mp: 62-65 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O
• InChI: 1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
• InChI key: YKPUWZUDDOIDPM-SOFGYWHQSA-N
• Gene Information: human ... TRPV1(7442)

Beschreibung

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Capsaicin USP reference standard for use in specified quality tests and assays.

Also used to prepare standard solutions for the assay, identification, composition and strength analysis according to the given below monographs of United States Pharmacopeia (USP):

• Capsaicin
• Capsicum Oleoresin
• Capsicum
• Ginger Tincture

Biochem/physiol Actions

Prototyp Vanilloid-Rezeptor-Agonist; Neurotoxin.

Prototyp Vanilloid-Rezeptoragonist; Neurotoxin; aktiviert sensorische Neuronen, was zu unmyelierten C-Fasern führt, von denen viele Substanz P enthalten. Topische Applikation desensibilisiert die sensorischen Nervenendigungen, was eine paradoxe antinozizeptive Wirkung ergibt; systemische Verabreichung kann neurotoxisch auf Capsaicin-sensitive Zellen wirken, insbesondere bei neugeborenen Tieren. Aktiver Bestandteil von Chilischoten.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• pictograms: GHS06,GHS08,GHS05
• signalword: Danger
• hcodes: H300,H315,H317,H318,H334,H335
• Hazard Classifications: Acute Tox. 2 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• flash_point_f: 235.4 °F - closed cup
• flash_point_c: 113 °C - closed cup
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338