1025205

Aminoglutethimid

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): DL-Aminoglutethimid
• Empirische Formel (Hill-System): C₁₃H₁₆N₂O₂
• CAS-Nummer: 125-84-8
• Molekulargewicht: 232.28
• MDL-Nummer: MFCD00010122
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329748993
• NACRES: NA.24

Eigenschaften

• Qualität: pharmaceutical primary standard
• Hersteller/Markenname: USP
• mp (Schmelzpunkt): 152-154 °C (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• SMILES String: CCC1(CCC(=O)NC1=O)c2ccc(N)cc2
• InChI: 1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
• InChIKey: ROBVIMPUHSLWNV-UHFFFAOYSA-N
• Angaben zum Gen: human ... CYP11A1(1583) , CYP19A1(1588)

Beschreibung

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem./physiol. Wirkung

DL-Aminoglutethimide is a derivative of the sedative glutethimide. Originally introduced as an anticonvulsant, it was found to cause adrenal insufficiency. Blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone. It also blocks the peripheral conversion (aromatization) of androgenic precursors to estrogens. The D-isomer is 30 times more potent at inhibiting aromatase activity, whereas the L-isomer is more potent at inhibiting cholesterol side-chain cleavage (steroidogenesis).

Hinweis zur Analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Sonstige Hinweise

USP issued SDS can be found here.

Sales restrictions may apply.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable