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1019701

USP

Amilorid -hydrochlorid

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

Amilorid -hydrochlorid Dihydrat, N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid -hydrochlorid Dihydrat

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PackungsgrößeSKUVerfügbarkeitPreis
500 mg
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€ 407,00

Über diesen Artikel

Empirische Formel (Hill-System):
C6H8ClN7O · HCl · 2H2O
CAS-Nummer:
Molekulargewicht:
302.12
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

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Unterstützung erhalten

grade

pharmaceutical primary standard

API family

amiloride

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Clc1nc(c(nc1N)N)C(=O)N\C(=N\[H])\N.Cl.O.O

InChI

1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2

InChI key

LTKVFMLMEYCWMK-UHFFFAOYSA-N

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Dieser Artikel
A7410Y00019021019712
manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

EDQM

manufacturer/tradename

USP

grade

pharmaceutical primary standard

grade

-

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

-

format

neat

format

neat

API family

amiloride

API family

-

API family

amiloride

API family

amiloride

General description

Amiloride hydrochloride is a photosensitive yellow powder used as a mild diuretic drug.[1]

Application

Amiloride hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Amiloride Hydrochloride and Hydrochlorothiazide Tablets
  • Amiloride Hydrochloride Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Lagerklasse

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Matthias Schoenberger et al.
Expert opinion on therapeutic patents, 23(10), 1383-1389 (2013-08-21)
Novel molecular platforms for epithelial sodium channel (ENaC) modulators are claimed in the following six patents: WO2012035158(A1); WO2009074575(A2); WO2011028740(A1); WO2009150137(A2); WO2011079087(A1); WO2008135557(A1). These ENaC inhibitors may be used in blocking transepithelial sodium and consequently water absorption across airway epithelia. This
Hector Rasgado-Flores et al.
American journal of physiology. Cell physiology, 305(11), C1114-C1122 (2013-08-30)
Hypertonic saline (HS) inhalation therapy benefits cystic fibrosis (CF) patients [Donaldson SH, Bennet WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. N Engl J Med 354: 241-250, 2006; Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks
Juraj Rievaj et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(4), G303-G313 (2013-06-15)
Intestinal calcium (Ca²⁺) absorption occurs via paracellular and transcellular pathways. Although the transcellular route has been extensively studied, mechanisms mediating paracellular absorption are largely unexplored. Unlike passive diffusion, secondarily active paracellular Ca²⁺ uptake occurs against an electrochemical gradient with water
Shujie Shi et al.
American journal of physiology. Renal physiology, 305(11), F1585-F1592 (2013-10-11)
The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (Po) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits
Robert W Hunter et al.
American journal of physiology. Renal physiology, 306(4), F457-F467 (2014-01-10)
Na(+) reabsorption from the distal renal tubule involves electroneutral and electrogenic pathways, with the latter promoting K(+) excretion. The relative activities of these two pathways are tightly controlled, participating in the minute-to-minute regulation of systemic K(+) balance. The pathways are

Global Trade Item Number

SKUGTIN
1019701-500MG04061838668691

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