V3890

VU0240551

≥98% (HPLC)

• Synonym(e): CID 7211972, N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]-acetamide, SID 56405457, VU0240551-1, VU0240551-2-D4
• Empirische Formel (Hill-System): C₁₆H₁₄N₄OS₂
• CAS-Nummer: 893990-34-6
• Molekulargewicht: 342.44
• NACRES: NA.77
• PubChem Substance ID: 329829046
• UNSPSC Code: 12352200
• MDL number: MFCD05957363
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1csc(NC(=O)CSc2ccc(nn2)-c3ccccc3)n1
• InChI: 1S/C16H14N4OS2/c1-11-9-23-16(17-11)18-14(21)10-22-15-8-7-13(19-20-15)12-5-3-2-4-6-12/h2-9H,10H2,1H3,(H,17,18,21)
• InChI key: WJRWSLORVIHRNX-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

VU0240551 is a potent, selective KCC2 inhibitor.

VU0240551 is a potent, selective KCC2 inhibitor. KCC2 is a potassium-chloride exchanger expressed specifically in neurons. KCC2 functions to lower intracellular chloride concentrations below the electrochemical potential of the cells, thereby increasing the hyperexcitability of the neurons. KCC2 activity enhances GABA and other inhibitory neurotransmission and is implicated in pain processing. VU0240551 was discovered in a high-throughput screen, followed by directed medicinal chemistry. VU0240551 is selective for KCC2 over NKCC1. VU0240551 binds competitively to the K+ site and binds noncompetitively to the Cl- site. VU0240551 is the only small molecule with specificity for a KCC family member.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable