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T9514

Sigma-Aldrich

Tetrahydropapaverine hydrochloride

≥90%, powder

Synonym(e):

6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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About This Item

Empirische Formel (Hill-System):
C20H25NO4 · HCl
CAS-Nummer:
6429-04-5
Molekulargewicht:
379.88
EG-Nummer:
229-213-9
MDL-Nummer:
MFCD00035267
UNSPSC-Code:
12352200

Assay

≥90%

Form

powder

Farbe

white

Löslichkeit

H2O: soluble

Lagertemp.

2-8°C

SMILES String

Cl.COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC

Biochem./physiol. Wirkung

Phosphodiesterase inhibitor.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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S Chulia et al.
British journal of pharmacology, 122(3), 409-416 (1997-11-14)
1. In the present work, the properties of 3-methyl isoquinoline, 3,4-dihydropapaverine, tetrahydropapaverine and tetrahydropapaveroline were compared with those of papaverine and laudanosine. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determination
K Suzuki et al.
Advances in neurology, 53, 215-218 (1990-01-01)
Effects of MPTP-like compounds on mitochondrial respiration, activity of NADH-ubiquinone oxidoreductase (complex I) and on ATP synthesis were reported. Mitochondria prepared from mouse whole brains were used. The compounds tested include tetrahydroisoquinoline (TIQ), tetrahydropapaveroline (THP), tetrahydropapaverine (THPV), and salsolinol. TIQ
K Suzuki et al.
Neurochemical research, 15(7), 705-710 (1990-07-01)
Since the discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism, it has been postulated that (a) MPTP-like toxin(s) such as 1,2,3,4-tetrahydroisoquinoline (TIQ) may induce Parkinson's disease. As the neuronal degeneration in MPTP-induced parkinsonism is thought to be caused by the inhibition of the
F S Messiha
Pharmacology, biochemistry, and behavior, 35(1), 29-33 (1990-01-01)
The in vivo effect of amantadine, chlorpromazine and reserpine on testicular aldehyde dehydrogenase (T-ALDH) was studied as a function of mouse strain. The effect of Leu-enkephalin and tetrahydropapaverine on rodent T-ALDH was also studied in vivo. The in vitro effect
Yunjo Soh et al.
Biological & pharmaceutical bulletin, 26(6), 803-807 (2003-06-17)
Protective effects of quinic acids from Aster scaber on tetrahydropapaveroline (THP)-induced cell toxicity were evaluated in rat C6 glioma cells. Among 4 quinic acid derivatives tested, (-) 4,5-dicaffeoyl quinic acid (QA3) exhibited the highest protective effect against THP-induced cell toxicity.
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