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T5830

Sigma-Aldrich

Trap-101 hydrochloride

≥98% (HPLC), powder

Synonym(e):

1-[1-(cyclooctylmethyl)-1,2,3,6-tetrahydro-5-(hydroxymethyl)-4-pyridinyl]-3-ethyl-1,3-dihydro-2Hbenzimidazol-2-one hydrochloride

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About This Item

Empirische Formel (Hill-System):
C24H35N3O2·HCl
CAS-Nummer:
1216621-00-9
Molekulargewicht:
434.01
MDL-Nummer:
MFCD09971083
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329826831
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to off-white

Löslichkeit

H2O: ≥10 mg/mL

Lagertemp.

2-8°C

SMILES String

Cl.CCN1C(=O)N(C2=C(CO)CN(CC2)CC3CCCCCCC3)c4ccccc14

InChI

1S/C24H35N3O2.ClH/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19;/h8-9,12-13,19,28H,2-7,10-11,14-18H2,1H3;1H

InChIKey

YEVMLMQAMCKVSC-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Trap-101 Hydrochloride is a nociceptin/orphanin FQ peptide (NOP) receptor blocker. Trap-101 acts as an inverse agonist. Trap-101 had been found to be an effective NOP receptor antagonist both in vitro and in vivo, with equivalent potency to J113397.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Wenhui Zhao et al.
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Diabetes confers a very high risk of lower-extremity amputation (LEA); however, few studies have assessed whether blood glucose control can reduce LEA risk among patients with diabetes, especially in practice settings where low-income patients predominate. We performed a prospective cohort
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The British journal of ophthalmology, 97(12), 1538-1542 (2013-09-26)
To evaluate the association between the magnitude of relative afferent pupillary defect (RAPD) and the laterality of visual fields in glaucoma patients using pupillography. Evaluations were made with an RAPDx (Konan Medical USA, Irvine, California, USA), which is designed to
Christian Dollendorf et al.
Beilstein journal of organic chemistry, 9, 1652-1662 (2013-09-26)
A redox-responsive polycationic system was synthesized via copolymerization of N,N-diethylacrylamide (DEAAm) and 2-(dimethylamino)ethyl methacrylate (DMAEMA). N,N'-bis(4-chlorobutanoyl)cystamine was used as disulfide-containing cross-linker to form networks by the quaternization of tertiary amine groups. The insoluble cationic hydrogels become soluble by reduction of
Katsumi Shibata et al.
Journal of nutritional science and vitaminology, 59(4), 343-346 (2013-09-26)
Most Japanese women do not consume the estimated average requirement of vitamin B6 (1.7 mg/d) during pregnancy. Nevertheless, these deficiencies are not reported. We investigated a nutritional biomarker of vitamin B6 in pregnant Japanese women as well as their vitamin
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