T4192

Tyrphostin SU 1498

≥98%

• Synonym(e): (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide
• Empirische Formel (Hill-System): C₂₅H₃₀N₂O₂
• CAS-Nummer: 168835-82-3
• Molekulargewicht: 390.52
• MDL-Nummer: MFCD03453026
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24900199

Eigenschaften

• Assay: ≥98%
• Form: solid
• Wirksamkeit: 700 nM IC₅₀
• Löslichkeit: DMSO: soluble
• Lagertemp.: −20°C
• SMILES String: CC(C)c1cc(\C=C(/C#N)C(=O)NCCCc2ccccc2)cc(C(C)C)c1O
• InChI: 1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
• InChIKey: JANPYFTYAGTSIN-FYJGNVAPSA-N

Beschreibung

Anwendung

Tyrphostin SU 1498 has been used as a VEGF inhibitor in mice¹.

Biochem./physiol. Wirkung

Potent and selective inhibitor of the VEGF receptor kinase, Flk-1. Very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase.

Angaben zur Herstellung

Tyrphostin SU 1498 is soluble in DMSO.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves